Electronic Properties of Synthetic Shrimp Pathogens-derived DNA Schottky Diodes

Rizan, Nastaran and Chan, Yen Yew and Niknam, Maryam Rajabpour and Krishnasamy, Jegenathan and Bhassu, Subha and Goh, Zee Hong and Devadas, Sridevi and Din, Mohamed Shariff Mohd and Tajuddin, Hairul Anuar and Othman, Rofina Yasmin and Phang, Siew Moi and Iwamoto, M. and Periasamy, Vengadesh (2018) Electronic Properties of Synthetic Shrimp Pathogens-derived DNA Schottky Diodes. Scientific Reports, 8 (1). p. 18825. ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-017-18825-6.

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Abstract

The exciting discovery of the semiconducting-like properties of deoxyribonucleic acid (DNA) and its potential applications in molecular genetics and diagnostics in recent times has resulted in a paradigm shift in biophysics research. Recent studies in our laboratory provide a platform towards detecting charge transfer mechanism and understanding the electronic properties of DNA based on the sequence-specific electronic response, which can be applied as an alternative to identify or detect DNA. In this study, we demonstrate a novel method for identification of DNA from different shrimp viruses and bacteria using electronic properties of DNA obtained from both negative and positive bias regions in current-voltage (I-V) profiles. Characteristic electronic properties were calculated and used for quantification and further understanding in the identification process. Aquaculture in shrimp industry is a fast-growing food sector throughout the world. However, shrimp culture in many Asian countries faced a huge economic loss due to disease outbreaks. Scientists have been using specific established methods for detecting shrimp infection, but those methods do have their significant drawbacks due to many inherent factors. As such, we believe that this simple, rapid, sensitive and cost-effective tool can be used for detection and identification of DNA from different shrimp viruses and bacteria.

Item Type:	Article
Funders:	Technofund (PV019-2016), FRGS (FP038-2017A), Prototype (RU005K-2016), PPP (PG231-2015A)
Uncontrolled Keywords:	Electronic Properties; Synthetic Shrimp Pathogens-derived; DNA; Schottky Diodes
Subjects:	Q Science > Q Science (General) Q Science > QC Physics Q Science > QD Chemistry Q Science > QH Natural history R Medicine
Divisions:	Faculty of Science Faculty of Science > Department of Physics Faculty of Science > Institute of Biological Sciences
Depositing User:	Ms. Juhaida Abd Rahim
Date Deposited:	07 Aug 2018 08:26
Last Modified:	03 Dec 2019 12:10
URI:	http://eprints.um.edu.my/id/eprint/18980

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