Sakai, N. and Alsaad, Z. and Thuong, N.T. and Shiota, K. and Yoneda, M. and Mohd, M.A. (2017) Source profiling of arsenic and heavy metals in the Selangor River basin and their maternal and cord blood levels in Selangor State, Malaysia. Chemosphere, 184. pp. 857-865. ISSN 0045-6535, DOI https://doi.org/10.1016/j.chemosphere.2017.06.070.
Full text not available from this repository.Abstract
Arsenic and 5 heavy metals (nickel, copper, zinc, cadmium and lead) were quantitated in surface water (n = 18) and soil/ore samples (n = 45) collected from 5 land uses (oil palm converted from forest, oil palm in peat swamp, bare land, quarry and forest) in the Selangor River basin by inductively coupled plasma mass spectrometry (ICP-MS). Geographic information system (GIS) was used as a spatial analytical tool to classify 4 land uses (forest, agriculture/peat, urban and bare land) from a satellite image taken by Landsat 8. Source profiling of the 6 elements was conducted to identify their occurrence, their distribution and the pollution source associated with the land use. The concentrations of arsenic, cadmium and lead were also analyzed in maternal blood (n = 99) and cord blood (n = 87) specimens from 136 pregnant women collected at the University of Malaya Medical Center for elucidating maternal exposure as well as maternal-to-fetal transfer. The source profiling identified that nickel and zinc were discharged from sewage and/or industrial effluents, and that lead was discharged from mining sites. Arsenic showed a site-specific pollution in tin-tungsten deposit areas, and the pollution source could be associated with arsenopyrite. The maternal blood levels of arsenic (0.82 ± 0.61 μg/dL), cadmium (0.15 ± 0.2 μg/dL) and lead (2.6 ± 2.1 μg/dL) were not significantly high compared to their acute toxicity levels, but could have attributable risks of chronic toxicity. Those in cord blood were significantly decreased in cadmium (0.06 ± 0.07 μg/dL) and lead (0.99 ± 1.2 μg/dL) but were equivalent in arsenic (0.82 ± 1.1 μg/dL) because of the different kinetics of maternal-to-fetal transfer.
| Item Type: | Article |
|---|---|
| Funders: | UM/MOE HIR Grant (E000005-20001), JSPS Bilateral Programs entitled “Implementation of locally-adapted health risk assessment in Malaysia based on local characteristics” |
| Uncontrolled Keywords: | Arsenic and heavy metals; Selangor River basin; Spatial analysis; Source profiling; Maternal blood levels; Maternal-to-fetal transfer |
| Subjects: | R Medicine R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 24 Jul 2017 06:35 |
| Last Modified: | 24 Jul 2017 06:35 |
| URI: | http://eprints.um.edu.my/id/eprint/17561 |
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