Sun, R.W.Y. and Zhang, M. and Li, D. and Zhang, Z.F. and Cai, H. and Li, M. and Xian, Y.J. and Ng, S.W. and Wong, A.S.T. (2015) Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework. Chemistry-A European Journal, 21 (51). pp. 18534-18538. ISSN 0947-6539,
Full text not available from this repository.Abstract
A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Cancer; Carbenes; Dithiocarbamate; Gold; Metal-Organic Frameworks |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Depositing User: | Mrs. Siti Mawarni Salim |
| Date Deposited: | 29 Jul 2016 07:58 |
| Last Modified: | 29 Jul 2016 07:58 |
| URI: | http://eprints.um.edu.my/id/eprint/16191 |
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