Li, Y. and Uenishi, R. and Hase, S. and Liao, H. and Li, Xiao-Jie and Tsuchiura, T. and Tee, K.K. and Pybus, O.G. and Takebe, Y. (2010) Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events. Virology, 402 (2). pp. 223-227.
Full text not available from this repository.Abstract
We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region. (C) 2010 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | HIV-1 subtype B'; Injecting drug user (IDU); Former plasma donor (FPD); Phylogeny; Bayesian coalescent analysis; Time of the most recent common ancestor (tMRCA); Southeast Asia; China |
| Subjects: | R Medicine |
| Depositing User: | Mr Faizal 2 |
| Date Deposited: | 11 Feb 2015 06:34 |
| Last Modified: | 11 Feb 2015 06:34 |
| URI: | http://eprints.um.edu.my/id/eprint/12693 |
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