Microwave-assisted fabrication of titanium implants with controlled surface topography for rapid bone healing

Kutty, M.G. and De, A. and Bhaduri, S.B. and Yaghoubi, A. (2014) Microwave-assisted fabrication of titanium implants with controlled surface topography for rapid bone healing. ACS Applied Materials & Interfaces, 16 (6). pp. 13587-13593. ISSN 1944-8244, DOI https://doi.org/10.1021/am502967n.

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Abstract

Morphological surface modifications have been reported to enhance the performance of biomedical implants. However, current methods of introducing graded porosity involves postprocessing techniques that lead to formation of microcracks, delamination, loss of fatigue strength, and, overall, poor mechanical properties. To address these issues, we developed a microwave sintering procedure whereby pure titanium powder can be readily densified into implants with graded porosity in a single step. Using this approach, surface topography of implants can be closely controlled to have a distinctive combination of surface area, pore size, and surface roughness. In this study, the effect of various surface topographies on in vitro response of neonatal rat calvarial osteoblast in terms of attachment and proliferation is studied. Certain graded surfaces nearly double the chance of cell viability in early stages (similar to one month) and are therefore expected to improve the rate of healing. On the other hand, while the osteoblast morphology significantly differs in each sample at different periods, there is no straightforward correlation between early proliferation and quantitative surface parameters such as average roughness or surface area. This indicates that the nature of cell-surface interactions likely depends on other factors, including spatial parameters.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	A paid open access option is available for this journal.
Uncontrolled Keywords:	Bone tissue engineering; Surface porosity; Roughness; Microwave; Sintering; Cell proliferation; Osteoblast; Porous-coated ti-6al-4v; Dental implants; Fatigue-strength; Oxide thickness; Roughness; Cells; Osseointegration; Proliferation; Osteoblast; Differentiation
Subjects:	R Medicine > RK Dentistry
Divisions:	Faculty of Dentistry
Depositing User:	Mr Ahmad Azwan Azman
Date Deposited:	20 Nov 2014 02:14
Last Modified:	20 Nov 2014 02:14
URI:	http://eprints.um.edu.my/id/eprint/11362

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