Antiobesity effect of caraway extract on overweight and obese women: a randomized, triple-blind, placebo-controlled clinical trial

Kazemipoor, Mahnaz and Wan Mohamed Radzi, Che Wan Jasimah and Hajifaraji, Majid and Haerian, Batoul Sadat and Mosaddegh, Mohammad Hossein and Cordell, Geoffrey A. (2013) Antiobesity effect of caraway extract on overweight and obese women: a randomized, triple-blind, placebo-controlled clinical trial. Evidence-Based Complementary and Alternative Medicine, 2013. p. 928582. ISSN 1741-427X, DOI https://doi.org/10.1155/2013/928582.

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Abstract

Caraway (Carum carvi L.), a potent medicinal plant, is traditionally used for treating obesity. This study investigates the weight-lowering effects of caraway extract (CE) on physically active, overweight and obese women through a randomized, triple-blind, placebo-controlled clinical trial. Seventy overweight and obese, healthy, aerobic-trained, adult females were randomly assigned to two groups (n - 35 per group). Participants received either 30 mL/day of CE or placebo without changing their diet or physical activity. Subjects were examined at baseline and after 90 days for changes in body composition, anthropometric indices, and clinical and paraclinical variables. The treatment group, compared with placebo, showed a significant reduction of weight, body mass index, body fat percentage, and waist-to-hip ratio. No changes were observed in lipid profile, urine-specific gravity, and blood pressure of subjects. The results suggest that a dietary CE with no restriction in food intake, when combined with exercise, is of value in the management of obesity in women wishing to lower their weight, BMI, body fat percentage, and body size, with no clinical side effects. In conclusion, results of this study suggest a possible phytotherapeutic approach for caraway extract in the management of obesity. This trial is registered with NCT01833377.

Item Type:	Article
Funders:	This study was partially supported by Research Grant no. RG108/11SUS, Department of Science & Technology Studies, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Uncontrolled Keywords:	Carum-Carvi-L.; N-3 Fatty-Acids; Essential Oils; Dietary-Supplements; Insulin-Resistance; Medicinal-Plants; Diabetic-Rats; Dose-Response; Antioxidant; Carvacrol
Subjects:	Q Science > Q Science (General) R Medicine R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Science > Department of Science and Technology Studies
Depositing User:	Ms Mahnaz Kazemipoor
Date Deposited:	08 Dec 2014 06:43
Last Modified:	29 Jan 2020 06:12
URI:	http://eprints.um.edu.my/id/eprint/11346

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