Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT

Aye, S.M.M. and Lim, K.S. and Ramli, N.M. and Tan, C.T. (2013) Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT. Lupus, 22 (5). pp. 510-514. ISSN 0961-2033, DOI https://doi.org/10.1177/0961203312474705.

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Abstract

This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus erythematosus (SLE) presented with a seizure followed by frontal lobe dysfunction clinically. An electroencephalogram (EEG) showed bilateral independent PLEDs in the frontal region. A magnetic resonance image of the brain showed white-matter changes in the frontal periventricular region. Cerebral angiogram did not reveal any evidence of vasculitis. A cerebral SPECT with tracer injected during the EEG showing PLEDs showed a reduction in CBF in the frontal regions. Clinical recovery was observed with intravenous immunoglobulin. This case shows that PLEDs can be seen with white-matter changes in SLE. Lupus (2013) 22, 510-514.

Item Type:	Article
Funders:	This work was supported by a University Malaya Research Grant (Reference No: RG 324/11HTM)
Additional Information:	ISI Document Delivery No.: 122TV Times Cited: 0 Cited Reference Count: 13 Aye, S. M. M. Lim, K. S. Ramli, N. M. Tan, C. T. University Malaya RG 324/11HTM This work was supported by a University Malaya Research Grant (Reference No: RG 324/11HTM). Sage publications ltd London
Uncontrolled Keywords:	PLEDs; SPECT; cerebral lupus; white matter
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms azrahani halim
Date Deposited:	08 Dec 2014 07:01
Last Modified:	08 Dec 2014 07:01
URI:	http://eprints.um.edu.my/id/eprint/11230

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