Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea

Baddam, Ramani and Thong, Kwai Lin and Avasthi, Tiruvayipati Suma and Shaik, Sabiha and Yap, Kien Pong and Teh, Cindy Shuan Ju and Chai, Lay Ching and Kumarasamy, Narender and Ahmed, Niyaz (2012) Whole-Genome Sequences and Comparative Genomics of Salmonella enterica Serovar Typhi Isolates from Patients with Fatal and Nonfatal Typhoid Fever in Papua New Guinea. Journal of Bacteriology, 194 (18). pp. 5122-5123. ISSN 0021-9193, DOI https://doi.org/10.1128/JB.01051-12.

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Abstract

Many of the developing countries of the Southeast Asian region are significantly affected by endemic typhoid fever, possibly as a result of marginal living standards. It is an important public health problem in countries such as Papua New Guinea, which is geographically close to some of the foci of endemicity in Asia. The severity of the disease varies in different regions, and this may be attributable to genetic diversity among the native strains. Genome sequence data on strains from different countries are needed to clearly understand their genetic makeup and virulence potential. We describe the genomes of two Salmonella Typhi isolates from patients with fatal and nonfatal cases of typhoid fever in Papua New Guinea. We discuss in brief the underlying sequencing methodology, assembly, genome statistics, and important features of the two draft genomes, which form an essential step in our functional molecular infection epidemiology program centering on typhoid fever. The comparative genomics of these and other isolates would enable us to identify genetic rearrangements and mechanisms responsible for endemicity and the differential severity of pathogenic salmonellae in Papua New Guinea and elsewhere.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Institute of Biological Sciences, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords:	Genomics; Salmonella enterica Serovar Typhi; Patients; Typhoid Fever; Papua New Guinea
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history Q Science > QR Microbiology
Divisions:	Faculty of Science > Institute of Biological Sciences
Depositing User:	Prof. Dr Kwai Lin Thong
Date Deposited:	14 Oct 2014 03:10
Last Modified:	03 Dec 2019 04:29
URI:	http://eprints.um.edu.my/id/eprint/10643

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