Kam, T.S. and Tan, S.J. and Robinson, W.T. and Komiyama, K. (2011) Macrodasines A—G, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuran—tetrahydrofuran and tetrahydrofuran—tetrahydropyran rings. Tetrahedron, 67. pp. 3830-3838. ISSN 0040-4020, DOI https://doi.org/10.1016/j.tet.2011.03.099.
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Abstract
The bark extract of the Malayan Alstonia angustifoliaWall provided the spirocyclic alkaloids macrodasines A—G. The structures of the new compounds were established by analysis of the spectroscopic data and in the case of macrodasines A and B confirmed by X-ray diffraction analysis. Macrodasines A, B, C, and G incorporate fused spirocyclic tetrahydrofuran—tetrahydrofuran rings, while macrodasines D, E, and F incorporate fused tetrahydrofuran—tetrahydropyran rings. Macrodasines B, C, and E were found to show moderate levels of activity in reversing multidrug-resistance in drug-resistant KB cells.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, University of Malaya |
| Uncontrolled Keywords: | Spirocyclic alkaloids; NMR; X-ray; Alstonia. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Suhaila Syakila Alby |
| Date Deposited: | 15 Oct 2014 01:51 |
| Last Modified: | 15 Oct 2014 01:51 |
| URI: | http://eprints.um.edu.my/id/eprint/10392 |
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