Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley

Sivasothy, Y. and Ibrahim, H. and Paliany, A.S. and Alias, S.A. and Awang, Khalijah (2013) Pahangensin A and B, two new antibacterial diterpenes from the rhizomes of Alpinia pahangensis Ridley. Bioorganic and Medicinal Chemistry Letters, 23. pp. 6280-6285. ISSN 0960-894X,

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Abstract

The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 lg/mL, respectively. Pahangensin B (2) exhibited antibacterial activity (MIC <100 lg/mL) against B. cereus.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Corresponding author. Tel.: +60 79674064; fax: +60 79674193. E-mail address: khalijah@um.edu.my (K. Awang). Department of Chemistry, Faculty of Science, University Malaya
Uncontrolled Keywords:	Alpinia pahangensis Ridley; Zingiberaceae; Bis-labdanic diterpene; Labdane diterpene; Pahangensin A; Pahangensin B; Antibacterial agent
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Science > Institute of Biological Sciences
Depositing User:	Ms. Jamilah Salleh
Date Deposited:	21 Oct 2014 04:15
Last Modified:	01 Mar 2019 09:18
URI:	http://eprints.um.edu.my/id/eprint/10109

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