Leong, K.H. (2012) Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae). Fitoterapia, 83 (8). pp. 1391-1395. DOI https://doi.org/10.1016/j.fitote.2012.10.004.
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Abstract
A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).
| Item Type: | Article |
|---|---|
| Funders: | Institute of Research Management and Monitoring (IPPP) (PS344/2009C), Fundamental Research Grant Scheme (FRGS) (FP006/2011A), Research University Grant (RP001/2012A) |
| Uncontrolled Keywords: | Aglaia exima; Meliaceae; Cycloartane; Cytotoxicity; Steroids; 24(E)-cycloart-24-ene-26-ol-3-one |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QK Botany R Medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Dr. Leong Kok Hoong |
| Date Deposited: | 22 May 2014 02:18 |
| Last Modified: | 31 Jul 2018 04:26 |
| URI: | http://eprints.um.edu.my/id/eprint/10001 |
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