Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff

Leong, K.H. (2012) Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff. Bioorganic & Medicinal Chemistry Letters, 22 (11). pp. 3831-3836. DOI https://doi.org/10.1016/j.bmcl.2012.02.064.

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Abstract

The rhizomes of Zingiber spectabile yielded a new dimeric flavonol glycoside for which the name kaempferol-3-O-(4″-O-acetyl)-α-l-rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4″-O-acetyl)-α-l-rhamnopyranoside; spectaflavoside A (1) was proposed, along with kaempferol and its four acetylrhamnosides (2–6), demethoxycurcumin (7) and curcumin (8). The structure of spectaflavoside A was elucidated by spectroscopic methods including, 1D and 2D NMR techniques. This is the first report on the occurrence of a dimeric flavonol glycoside in the Zingiberaceae and the second in nature. Spectaflavoside A was found to be a potent iron chelating agent.

Item Type:	Article
Funders:	Research University Grant RG 017/09 SUS and RG 008-09B10 , 16-02-03-6024 provided by MOSTI , 05-01-05SF01001 Escience Fund provided by the Ministry of Agriculture and Agro-based Industry Malaysia
Uncontrolled Keywords:	Zingiber spectabile Griff.; Zingiberaceae; Dimeric flavonol glycoside; Bisflavonol glycoside; Spectaflavoside A; Iron chelating activity
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology Q Science > QK Botany R Medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Faculty of Medicine
Depositing User:	Dr. Leong Kok Hoong
Date Deposited:	22 May 2014 02:21
Last Modified:	31 Jul 2018 04:26
URI:	http://eprints.um.edu.my/id/eprint/10000

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