Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1

Kassim, M. and Yusoff, K.M. and Ong, G. and Sekaran, S. and Yusof, M.Y.B.M. and Mansor, M. (2012) Gelam honey inhibits lipopolysaccharide-induced endotoxemia in rats through the induction of heme oxygenase-1 and the inhibition of cytokines, nitric oxide, and high-mobility group protein B1. Fitoterapia, 83 (6). pp. 1054-1059. ISSN 0367-326X

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Abstract

Malaysian Gelam honey has anti-inflammatory and antibacterial properties, a high antioxidant capacity, and free radical-scavenging activity. Lipopolysaccharide (LPS) stimulates immune cells to sequentially release early pro- and anti-inflammatory cytokines and induces the synthesis of several related enzymes. The aim of this study was to investigate the effect of the intravenous injection of honey in rats with LPS-induced endotoxemia. The results showed that after 4 h of treatment, honey reduced cytokine (tumor necrosis factor-α, interleukins 1β, and 10) and NO levels and increased heme oxygenase-1 levels. After 24 h, a decrease in cytokines and NO and an increase in HO-1 were seen in all groups, whereas a reduction in HMGB1 occurred only in the honey-treated groups. These results support the further examination of honey as a natural compound for the treatment of a wide range of inflammatory diseases. © 2012 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Honey; Endotoxemia; Cytokines; High-mobility group box 1; Nitric oxide; Heme oxygenase-1
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 08 Jul 2013 06:39
Last Modified: 08 Jul 2013 06:39
URI: http://eprints.um.edu.my/id/eprint/7961

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