Thiha, Aung and Ibrahim, Fatimah and Joseph, Karunan and Petrovic, Bojan and Kojic, Sanja and Dahlan, Nuraina Anisa and Jamaluddin, Nurul Fauzani and Qureshi, Saima and Stojanovic, Goran M. (2023) A novel microfluidic compact disc to investigate electrochemical property changes between artificial and real salivary samples mixed with mouthwashes using electrical impedance analysis. PLoS ONE, 18 (2). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0280381.
Full text not available from this repository.Abstract
Diagnosing oral diseases at an early stage may lead to better preventive treatments, thus reducing treatment burden and costs. This paper introduces a systematic design of a microfluidic compact disc (CD) consisting of six unique chambers that run simultaneously from sample loading, holding, mixing and analysis. In this study, the electrochemical property changes between real saliva and artificial saliva mixed with three different types of mouthwashes (i.e. chlorhexidine-, fluoride- and essential oil (Listerine)-based mouthwashes) were investigated using electrical impedance analysis. Given the diversity and complexity of patient's salivary samples, we investigated the electrochemical impedance property of healthy real saliva mixed with different types of mouthwashes to understand the different electrochemical property which could be a foundation for diagnosis and monitoring of oral diseases. On the other hand, electrochemical impedance property of artificial saliva, a commonly used moisturizing agent and lubricant for the treatment of xerostomia or dry mouth syndrome was also studied. The findings indicate that artificial saliva and fluoride-based mouthwash showed higher conductance values compared to real saliva and two other different types of mouthwashes. The ability of our new microfluidic CD platform to perform multiplex processes and detection of electrochemical property of different types of saliva and mouthwashes is a fundamental concept for future research on salivary theranostics using point-of-care microfluidic CD platform.
| Item Type: | Article |
|---|---|
| Funders: | Horizon 2020 Framework Programme, H2020 Marie Skłodowska-Curie Actions [Grant no. 854194, 872370, IIRG002A-2022HWB], Universiti Malaya [Grant no. RK006-2021] |
| Uncontrolled Keywords: | Chlorhexidine; Electric Impedance; Fluorides; Humans; Microfluidics; Mouthwashes; Saliva; Saliva, Artificial; Xerostomia |
| Subjects: | R Medicine T Technology > TA Engineering (General). Civil engineering (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Divisions: | Faculty of Engineering > Department of Biomedical Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 23 Oct 2025 21:20 |
| Last Modified: | 23 Oct 2025 21:20 |
| URI: | http://eprints.um.edu.my/id/eprint/48393 |
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