Ng, Wei Wen and Ab Naim, Wan Naimah Wan and Liew, Yih Miin and Chan, Bee Ting (2024) Estimation of In-Vivo Mechanical Properties of Aortic Wall in Left Ventricular Hypertrophy Patients. In: 2024 8th International Conference on Biomedical Engineering and Applications, ICBEA 2024, 18-21 March 2024, Tokyo, Japan.
Full text not available from this repository.Abstract
Aortic wall properties such as aortic stiffness has emerged as a good tool for risk stratification because it has been linked to increased risk of heart disease. Thus, this preliminary study aims to estimate the in-vivo aortic wall properties between healthy and hypertrophy heart disease patients. Cine magnetic resonance (CMR) images of six human subjects i.e. two healthy subjects, two hypertrophy cardiomyopathy (HCM) and two hypertensive heart disease (HHD) patients were obtained. Based on the CMR images, aortic wall deformation at the ascending, arch and descending aorta were acquired at both systolic and diastolic phases. The stress and strain were then calculated and Mooney-Rivlin and Ogden hyperelastic material models were adopted to estimate the material constants at the respective regions in both phases. All the subjects were further categorized into two age groups to compare the effects of aging. Our results show that five parameters Mooney-Rivlin model has better fit of stress-strain data while the aortic wall stress is most prominent in the ascending aorta region. The greatest systolic aortic stress at the ascending aorta was found in HHD patients (238.17 kPa) followed by HCM patients (173.61 kPa) and lowest in healthy subjects (141.06 kPa). For aortic strain, an inverse trend was observed among the subjects. The older age group demonstrated a smaller aortic strain (22.60%) compared to the slightly younger age group (38.73%). This study shows that the estimated aortic wall stiffness in HHD and HCM are greater than the healthy subjects while the effect of aging is more prominent on aortic wall stiffness.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Funders: | University of Nottingham Malaysia Pump Priming Grant (PV005-2022) |
| Additional Information: | 8th International Conference on Biomedical Engineering and Applications (ICBEA), Tokyo, JAPAN, MAR 18-21, 2024 |
| Uncontrolled Keywords: | Aorta; stiffness; isotropic; hypertrophy |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Faculty of Engineering > Department of Biomedical Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 26 May 2025 01:13 |
| Last Modified: | 26 May 2025 01:13 |
| URI: | http://eprints.um.edu.my/id/eprint/48063 |
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