Vitus, Vieralynda and Ibrahim, Fatimah and Shamsuddin, Shamsul Azlin Ahmad and Razali, Nuguelis and Noor Azlan, Noor Anastasha Balqis and Zaman, Wan Safwani Wan Kamarul (2022) Carbonised Human Hair Incorporated in Agar/KGM Bioscaffold for Tissue Engineering Application: Fabrication and Characterisation. POLYMERS, 14 (24). ISSN 2073-4360, DOI https://doi.org/10.3390/polym14245489.
Full text not available from this repository.Abstract
Carbon derived from biomass waste usage is rising in various fields of application due to its availability, cost-effectiveness, and sustainability, but it remains limited in tissue engineering applications. Carbon derived from human hair waste was selected to fabricate a carbon-based bioscaffold (CHAK) due to its ease of collection and inexpensive synthesis procedure. The CHAK was fabricated via gelation, rapid freezing, and ethanol immersion and characterised based on their morphology, porosity, Fourier transforms infrared (FTIR), tensile strength, swelling ability, degradability, electrical conductivity, and biocompatibility using Wharton's jelly-derived mesenchymal stem cells (WJMSCs). The addition of carbon reduced the porosity of the bioscaffold. Via FTIR analysis, the combination of carbon, agar, and KGM was compatible. Among the CHAK, the 3HC bioscaffold displayed the highest tensile strength (62.35 +/- 29.12 kPa). The CHAK also showed excellent swelling and water uptake capability. All bioscaffolds demonstrated a slow degradability rate (<50%) after 28 days of incubation, while the electrical conductivity analysis showed that the 3AHC bioscaffold had the highest conductivity compared to other CHAK bioscaffolds. Our findings also showed that the CHAK bioscaffolds were biocompatible with WJMSCs. These findings showed that the CHAK bioscaffolds have potential as bioscaffolds for tissue engineering applications.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya Impact-Oriented Interdisciplinary Research Grant Program [IIRG007A-19HWB] |
| Uncontrolled Keywords: | human hair; carbon; pyrolysis; biocompatibility; Wharton's jelly-derived mesenchymal stem cells |
| Subjects: | S Agriculture > S Agriculture (General) T Technology > T Technology (General) |
| Divisions: | Faculty of Engineering > Biomedical Engineering Department Faculty of Medicine > Obstetrics & Gynaecology Department Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Koh Ai Peng |
| Date Deposited: | 29 Oct 2024 06:48 |
| Last Modified: | 29 Oct 2024 06:48 |
| URI: | http://eprints.um.edu.my/id/eprint/46143 |
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