Bukhari, Syed N. A. and Tandiary, Michael A. and Al-Sanea, Mohammad M. and Abdelgawad, Mohamed A. and Chee, Chin Fei and Hussain, Muhammad A. (2022) Small molecules as LIM kinase inhibitors. Current Medicinal Chemistry, 29 (17). pp. 2995-3027. DOI https://doi.org/10.2174/0929867328666211026120335.
Full text not available from this repository.Abstract
LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies have been carried out to discover small organic molecules capable of inhibiting LIM kinase effectively and selectively. In this review, a comprehensive survey of small organic molecules for LIM kinase inhibitors is reported, together with SAR study results, and the synthesis of these inhibitors.
| Item Type: | Article |
|---|---|
| Funders: | Deanship of Scientific Research at Jouf University ]DSR-2021-01-0208] |
| Uncontrolled Keywords: | Cytoskeleton; Thiazole; Thienopyridine Derivatives; Thienopyrimidine; Synthesis; LIM Kinase |
| Subjects: | T Technology > T Technology (General) |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Oct 2023 08:27 |
| Last Modified: | 18 Oct 2023 08:27 |
| URI: | http://eprints.um.edu.my/id/eprint/42090 |
Actions (login required)
 |
View Item |
