Mucuna pruriens Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats

Fung, S.Y.; Tan, N.H.; Sim, S.M.; Marinello, E.; Guerranti, R. (2011) Mucuna pruriens Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats. Indian Journal of Experimental Biology, 49 (4). pp. 254-259. ISSN 0019-5189

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    Abstract

    Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatrix venom. These may be explained at least in part by the neutralisation of the cobra venom toxins by anti-MPE antibodies elicited by the MPE pretreatment.

    Item Type: Article
    Creators:
    1. Fung, S.Y.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    2. Tan, N.H.
    3. Sim, S.M.
    4. Marinello, E.
    5. Guerranti, R.
    Journal or Publication Title: Indian Journal of Experimental Biology
    Uncontrolled Keywords: Antivenom effects Immunology Mucuna pruriens seed Naja sputatrix venom
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Fung Shin Yee
    Date Deposited: 27 Sep 2012 11:00
    Last Modified: 27 Sep 2012 11:00
    URI: http://eprints.um.edu.my/id/eprint/3697

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