Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes

Poh, R.; Muniandy, S. (2010) Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes. Southeast Asian Journal of Tropical Medicine & Public Health, 41 (5). pp. 1231-1246. ISSN 0038-3619

[img]
Preview
PDF - Published Version [error in script]
Download (113Kb) | Preview

    Abstract

    The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a reduction in activity towards paraoxon was associated with a significant increase in risk (p=0.023) for cardiovascular disease complications in diabetic patients. Multivariate analysis of two plasma measures of paraoxonase activity using paraoxon and diazoxon also showed reduced paraoxonase activity towards paraoxon was associated with a significant increase in risk (p=0.045) for cardiovascular disease complications in diabetic patients. These analyses showed that a reduced paraoxonase activity towards paraoxon was associated with ethnicity. Based on multivariate analysis, subjects of Malay ethnic origin have significantly higher than expected activity (p=0.008, compared to Indians), towards paraoxon than subjects of Chinese origin who in turn had higher than expected paraoxonase activity (p=0.028, compared to Indians) Indian subjects.

    Item Type: Article
    Creators:
    1. Poh, R.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    2. Muniandy, S.
    Journal or Publication Title: Southeast Asian Journal of Tropical Medicine & Public Health
    Additional Information: Correspondence: Rozaida Poh Yuen Ying, Department of Molecular Medicine, Faculty of Medicine, University of Malaya 50603, Kuala Lumpur, Malaysia. Tel: +603-79676611; Fax: +603-79676600 E-mail: rozaiday@um.edu.my
    Uncontrolled Keywords: paraoxonase 1, cardiovascular disease, type 2 diabetes
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 12 Sep 2012 11:19
    Last Modified: 12 Sep 2012 11:19
    URI: http://eprints.um.edu.my/id/eprint/3662

    Actions (For repository staff only: Login required)

    View Item

    Document Downloads

    More statistics for this item...