Christakoudi, Sofia and Tsilidis, Konstantinos K. and Muller, David C. and Freisling, Heinz and Weiderpass, Elisabete and Overvad, Kim and Soederberg, Stefan and Haeggstroem, Christel and Pischon, Tobias and Dahm, Christina C. and Zhang, Jie and Tjonneland, Anne and Halkjaer, Jytte and MacDonald, Conor and Boutron-Ruault, Marie-Christine and Mancini, Francesca Romana and Kuehn, Tilman and Kaaks, Rudolf and Schulze, Matthias B. and Trichopoulou, Antonia and Karakatsani, Anna and Peppa, Eleni and Masala, Giovanna and Pala, Valeria and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and Quiros, J. Ramon and Agudo, Antonio and Sanchez, Maria-Jose and Cirera, Lluis and Barricarte-Gurrea, Aurelio and Amiano, Pilar and Memarian, Ensieh and Sonestedt, Emily and Bueno-de-Mesquita, Bas and May, Anne M. and Khaw, Kay-Tee and Wareham, Nicholas J. and Tong, Tammy Y. N. and Huybrechts, Inge and Noh, Hwayoung and Aglago, Elom K. and Ellingjord-Dale, Merete and Ward, Heather A. and Aune, Dagfinn and Riboli, Elio (2020) A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: Results from a large European cohort. Scientific Reports, 10 (1). ISSN 20452322, DOI https://doi.org/10.1038/s41598-020-71302-5.
Full text not available from this repository.Abstract
Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI<greater than or equal to>30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.
| Item Type: | Article |
|---|---|
| Funders: | UK Research & Innovation (UKRI) Medical Research Council UK (MRC) [Grant No: MC_UU_00006/1], UK Research & Innovation (UKRI) Medical Research Council UK (MRC) [Grant No: MR/N003284/1] |
| Uncontrolled Keywords: | All-Cause Mortality; Anthropometric; Measures; Mass index; Overweight; Cancer prediction; Adiposity; Size |
| Subjects: | Q Science > Q Science (General) T Technology > T Technology (General) |
| Divisions: | Faculty of Medicine > Social & Preventive Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 26 Nov 2024 08:25 |
| Last Modified: | 26 Nov 2024 08:25 |
| URI: | http://eprints.um.edu.my/id/eprint/36408 |
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