KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects

Saif-Ali, R.; Muniandy, S.; Al-Hamodi, Z.; Lee, C.S.; Ahmed, K.A.; Al-Mekhlafi, A.M.; Ismail, I.S. (2011) KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects. Annals of the Academy of Medicine, Singapore, 40 (11). ISSN 0304-4602

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Abstract

INTRODUCTION: Type 2 diabetes (T2D) candidate gene: potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) was suggested by conducting a genome wide association study (GWAS) in Japanese population. Association studies have been replicated among East Asian populations; however, the association between this gene and T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of KCNQ1 common variants with type 2 diabetes in Malaysian Malay subjects. MATERIALS AND METHODS: The KCNQ1 single nucleotide polymorphisms (SNPs): rs2237892, rs2283228, and rs2237895 were genotyped in 234 T2D and 177 normal Malay subjects. RESULTS: The risk allele of the rs2283228 (A) was strongly associated with T2D (OR = 1.7, P = 0.0006) while the rs2237892 (C) was moderately associated with T2D (OR = 1.45, P = 0.017). The recessive genetic models showed that rs2283228 was strongly associated with T2D (OR = 2.35, P = 0.00005) whereas rs2237892 showed a moderate association with T2D (OR = 1.69, P = 0.01). The haplotype block (TCA), which contained the protective allele, correlated with a protection from T2D (OR = 0.5, P = 0.003). Furthermore, the diplotype (CAA-TCA) that contained the protective haplotype was protected against T2D (OR = 0.46, P = 0.006). CONCLUSION: The KCNQ1 SNPs, haplotypes and diplotypes are associated with T2D in the Malaysian Malay subjects.

Item Type: Article
Creators:
  1. Saif-Ali, R.
  2. Muniandy, S.
  3. Al-Hamodi, Z.
  4. Lee, C.S.
  5. Ahmed, K.A.
  6. Al-Mekhlafi, A.M.
  7. Ismail, I.S.
Journal or Publication Title: Annals of the Academy of Medicine, Singapore
Additional Information: Department of Molecular Medicine, Faculty of Medicine, University Malaya, Malaysia. reyadh70@yahoo.com
Uncontrolled Keywords: Molecular Medicine; Adult; Diabetes Mellitus, Type 2/ethnology; Diabetes Mellitus, Type 2/genetics
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 04 Jul 2012 09:28
Last Modified: 04 Jul 2012 09:28
URI: http://eprints.um.edu.my/id/eprint/3468

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