Can the acute-phase reactant proteins be used as cancer biomarkers?

Pang, W.W. and Abdul-Rahman, P.S. and Wan-Ibrahim, W.I. and Hashim, Onn Haji (2010) Can the acute-phase reactant proteins be used as cancer biomarkers? International Journal of Biological Markers, 25 (1). pp. 1-11. ISSN 0393-6155

[img] PDF
Can_the_acute-phase_reactant_proteins_be_used_as_cancer_biomarkers.pdf - Published Version
Restricted to Registered users only

Download (952kB) | Request a copy
Official URL: http://www.utoronto.ca/acdclab/pubs/ed/20155712.pd...

Abstract

The association between the acute-phase reactant proteins (APRPs) and cancer has long been established. There have been numerous reports correlating altered levels of various APRPs with different types of cancers. However, researchers are often quick to dismiss the use of these APRPs as potential biomarkers for the diagnosis and monitoring of cancer because alterations in APRP concentrations are observed in a wide range of diseases. Recent progress in proteomics studies which profiled the serum proteins of cancer patients and those of normal individuals indicated that the altered APRP expressions were different for distinct types, subtypes, and even stages of cancer. Interestingly, these data are in agreement with those observed earlier using immunochemical and biochemical assays. In view of this compelling association of different patterns of APRPs with various types of cancers and in an apparent shift of paradigm, we present in this review some indications that APRP fingerprinting may be used as complementary cancer biomarkers. (Int J Biol Markers 2010: 25: 1-11)

Item Type: Article
Additional Information: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur - Malaysia
Uncontrolled Keywords: Acute-phase reactant proteins, Biomarker, Cancer, Diagnosis, Serum
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 09 Jul 2012 08:52
Last Modified: 24 Oct 2019 08:24
URI: http://eprints.um.edu.my/id/eprint/3432

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year