Can the acute-phase reactant proteins be used as cancer biomarkers?

Pang, W.W.; Abdul-Rahman, P.S.; Wan-Ibrahim, W.I.; Hashim, O.H. (2010) Can the acute-phase reactant proteins be used as cancer biomarkers? International Journal of Biological Markers, 25 (1). pp. 1-11. ISSN 0393-6155

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    The association between the acute-phase reactant proteins (APRPs) and cancer has long been established. There have been numerous reports correlating altered levels of various APRPs with different types of cancers. However, researchers are often quick to dismiss the use of these APRPs as potential biomarkers for the diagnosis and monitoring of cancer because alterations in APRP concentrations are observed in a wide range of diseases. Recent progress in proteomics studies which profiled the serum proteins of cancer patients and those of normal individuals indicated that the altered APRP expressions were different for distinct types, subtypes, and even stages of cancer. Interestingly, these data are in agreement with those observed earlier using immunochemical and biochemical assays. In view of this compelling association of different patterns of APRPs with various types of cancers and in an apparent shift of paradigm, we present in this review some indications that APRP fingerprinting may be used as complementary cancer biomarkers. (Int J Biol Markers 2010: 25: 1-11)

    Item Type: Article
    1. Pang, W.W.
    2. Abdul-Rahman, P.S.
    3. Wan-Ibrahim, W.I.
    4. Hashim, O.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    Journal or Publication Title: International Journal of Biological Markers
    Additional Information: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur - Malaysia
    Uncontrolled Keywords: Acute-phase reactant proteins, Biomarker, Cancer, Diagnosis, Serum
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 09 Jul 2012 16:52
    Last Modified: 09 Jul 2012 16:52

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