Yap, Polly Soo Xi and Chong, Chun Wie and Ahmad Kamar, Azanna and Yap, Ivan Kok Seng and Choo, Yao Mun and Lai, Nai Ming and Teh, Cindy Shuan Ju (2021) Neonatal intensive care unit (NICU) exposures exert a sustained influence on the progression of gut microbiota and metabolome in the first year of life. Scientific Reports, 11 (1). ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-020-80278-1.
Full text not available from this repository.Abstract
Emerging evidence has shown a link between the perturbations and development of the gut microbiota in infants with their immediate and long-term health. To better understand the assembly of the gut microbiota in preterm infants, faecal samples were longitudinally collected from the preterm (n=19) and term (n=20) infants from birth until month 12. 16S rRNA gene sequencing (n=141) and metabolomics profiling (n=141) using nuclear magnetic resonance spectroscopy identified significant differences between groups in various time points. A panel of amino acid metabolites and central metabolism intermediates significantly correlated with the relative abundances of 8 species of bacteria were identified in the preterm group. In contrast, faecal metabolites of term infants had significantly higher levels of metabolites which are commonly found in milk such as fucose and beta -hydroxybutyrate. We demonstrated that the early-life factors such as gestational age, birth weight and NICU exposures, exerted a sustained effect to the dynamics of gut microbial composition and metabolism of the neonates up to one year of age. Thus, our findings suggest that intervention at this early time could provide `metabolic rescue' to preterm infants from aberrant initial gut microbial colonisation and succession.
| Item Type: | Article |
|---|---|
| Funders: | United States Naval Medical Research Unit [IF004-2020], Postgraduate Research Funding [(PPP: PG179-2015A)] |
| Uncontrolled Keywords: | Intestinal microbiota; Young-adults; Born preterm; Dynamics; Risk; Infants; Colonization; Hypertension; Propionate; Obesity |
| Subjects: | Q Science > Q Science (General) T Technology > T Technology (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 22 Aug 2022 04:36 |
| Last Modified: | 22 Aug 2022 04:36 |
| URI: | http://eprints.um.edu.my/id/eprint/28752 |
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