Arigela, Chandra Sekhar and Nelli, Giribabu and Gan, Siew Hua and Sirajudeen, Kuttulebbai Nainamohamed Salam and Krishnan, Kumarathevan and Abdul Rahman, Nurhanan and Pasupuleti, Visweswara Rao (2021) Bitter gourd honey ameliorates hepatic and renal diabetic complications on type 2 diabetes rat models by antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. Foods, 10 (11). ISSN 2304-8158, DOI https://doi.org/10.3390/foods10112872.
Full text not available from this repository.Abstract
Honey has several pharmacological effects, including anti-diabetic activity. However, the effectiveness of bitter gourd honey (BGH) in the treatment of diabetes mellitus (DM) is unknown. The aim of this study was to determine the antioxidant, anti-inflammatory, and anti-apoptotic properties of BGH on the kidney and liver of a streptozotocin-induced diabetes rat model. Methods: A single dose (nicotinamide 110 mg/kg, streptozotocin (STZ) 55 mg/kg, intraperitoneal (i.p.)) was used to induce DM in male rats. For 28 days, normal or diabetic rats were administered 1 g/kg/day and 2 g/kg/day of BGH orally. After the treatment, blood, liver, and kidney samples were collected and analysed for biochemical, histological, and molecular parameters. In addition, liquid chromatography-mass spectrometry (LC-MS) was used to identify the major bioactive components in BGH. Results: The administration of BGH to diabetic rats resulted in significant reductions in alanine transaminase (ALT),aspartate aminotransferase (AST), creatinine, and urea levels. Diabetic rats treated with BGH showed lesser pathophysiological alterations in the liver and kidney as compared to non-treated control rats. BGH-treated diabetic rats exhibited reduced levels of oxidative stress (MDA levels), inflammatory (MYD88, NFKB, p-NFKB, IKK beta), and apoptotic (caspase-3) markers, as well as higher levels of antioxidant enzymes (SOD, CAT, and GPx) in the liver and kidney. BGH contains many bioactive compounds that may have antioxidative stress, anti-inflammatory, and anti-apoptotic effects. Conclusion: BGH protected the liver and kidney in diabetic rats by reducing oxidative stress, inflammation, and apoptosis-induced damage. As a result, BGH can be used as a potential therapy to ameliorate diabetic complications.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia from the Fundamental Research Grant (FRGS) (R/FRGS/ A0700/01147A/004/2018/00551) (R/FRGS/A1300/01095A 003/2018/00551) |
| Uncontrolled Keywords: | Diabetes mellitus; Oxidative stress; Antioxidant enzymes; Inflammation |
| Subjects: | Q Science > Q Science (General) T Technology > T Technology (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 03 Mar 2022 01:10 |
| Last Modified: | 03 Mar 2022 01:10 |
| URI: | http://eprints.um.edu.my/id/eprint/28567 |
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