Structure−Activity Relationship of Polyisoprenyl Benzophenones fromGarcinia pyriferaon the Tubulin/Microtubule System

Roux, Delphine and A. Hadi, A. Hamid and Thoret, Sylviane and Guénard, Daniel and Thoison, Odile and Païs, Mary and Sévenet, Thierry (2000) Structure−Activity Relationship of Polyisoprenyl Benzophenones fromGarcinia pyriferaon the Tubulin/Microtubule System. Journal of Natural Products, 63 (8). pp. 1070-1076. ISSN 0163-3864

Full text not available from this repository.
Official URL: https://doi.org/10.1021/np0000872

Abstract

Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in Malaysia. A structure - activity relationship study, including natural and semisynthetic derivatives, delineated some structural features necessary for the interaction with tubulin within this compound class.

Item Type: Article
Uncontrolled Keywords: Benzophenones; Butadienes; Chromatography, Gel; Chromatography, High Pressure Liquid; Fruit; Gas Chromatography-Mass Spectrometry; Hemiterpenes; Humans; KB Cells; Magnetic Resonance Spectroscopy; Malaysia; Microtubules; Optical Rotation; Pentanes; Plants, Medicinal; Rosales; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tubulin
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 02 Sep 2021 03:35
Last Modified: 02 Sep 2021 03:35
URI: http://eprints.um.edu.my/id/eprint/26018

Actions (login required)

View Item View Item