Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta

Ajay, M.; Gilani, A.H.; Mustafa, M.R. (2003) Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sciences, 74 (5). pp. 603-612. ISSN 0024-3205

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    The potency, structure-activity relationship, and mechanism of vasorelaxation of a series of flavonoids, representing different subclasses (flavonols: fisetin, rutin, quercetin; flavones: chrysin, flavone, baicalein; flavanones: naringenin, naringin; isoflavones: diadzein and flavanes: epigallo catechin gallate), were examined in the isolated rat aorta. Most of the flavonoids tested showed concentration dependent relaxant effects against K +(80 mM) and phenylephrine (PE, 0.1 AM)-induced contractions with a greater inhibition of the responses to the a1-adrenoceptor agonist. The relaxant effects of most of the flavonoids involve in part the release of nitric oxide and prostaglandins from the endothelium as pretreatment with L-NAME and indomethacin attenuated the responses. In addition, the relaxant action of the flavonoids includes inhibition of Ca + 2 influx and release of Ca + 2 from intracellular stores. A structure-activity relationship amongst the flavonoids was suggested.

    Item Type: Article
    1. Ajay, M.
    2. Gilani, A.H.
    3. Mustafa, M.R.
    Journal or Publication Title: Life Sciences
    Additional Information: Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Uncontrolled Keywords: Rat aorta; Flavonoids; Vasorelaxant; Structure-activity relationship
    Subjects: R Medicine > R Medicine (General)
    R Medicine > RM Therapeutics. Pharmacology
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 18 Jan 2012 10:20
    Last Modified: 20 Oct 2014 16:18
    URI: http://eprints.um.edu.my/id/eprint/2463

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