Autoclave-assisted synthesis of AgNPs in Z. officinale extract and assessment of their cytotoxicity, antibacterial and antioxidant activities

Kalantari, Katayoon and Afifi, Amalina Muhammad and Moniri, Mona and Moghaddam, Amin Boroumand and Kalantari, Alireza and Izadiyan, Zahra (2019) Autoclave-assisted synthesis of AgNPs in Z. officinale extract and assessment of their cytotoxicity, antibacterial and antioxidant activities. IET Nanobiotechnology, 13 (3). pp. 262-268. ISSN 1751-8741

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Official URL: https://doi.org/10.1049/iet-nbt.2018.5066

Abstract

In this study, the authors synthesised silver nanoparticles (AgNPs) using autoclave as a simple, unique and eco-friendly approach. The effect of Zingiber officinale extract was evaluated as a reducing and stabiliser agent. According to transmission electron microscopy results, the AgNPs were in the spherical shape with a particle size of ∼17 nm. The biomedical properties of AgNPs as antibacterial agents and free radical scavenging activity were estimated. Synthesised AgNPs showed significant 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging. Strong bactericidal activity was shown by the AgNPs on Gram-positive and Gram-negative bacteria. A maximum inhibition zone of ∼14 mm was obtained for epidermidis at a concentration of 60 μg/ml for sample fabricated at 24 h. The AgNPs also showed a significant cytotoxic effect against MCF-7 breast cancer cell lines with an half maximal inhibitory concentration value of 62 μg/ml in 24 h by the MTT assay. It could be concluded that Z. officinale extract can be used effectively in the production of potential antioxidant and antimicrobial AgNPs for commercial application. © The Institution of Engineering and Technology 2018.

Item Type: Article
Uncontrolled Keywords: Nanoparticles; Silver; Synthesized nanoparticles
Subjects: T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 06 Apr 2020 15:40
Last Modified: 06 Apr 2020 15:40
URI: http://eprints.um.edu.my/id/eprint/24156

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