Salleh, H.M. and Chong, Soon Lim and Othman, Rozana and Hazni, Hazrina and Ahmad, Khadher and Mohd Yusoff, Mohd Yakub @ Zulkifli and Fauzi, Nurulwahidah and Wahab, Habibah A. and Liew, Sook Yee and Awang, Khalijah (2019) Dengue protease inhibition activity of selected malaysian medicinal herbs. Tropical Biomedicine, 36 (2). pp. 357-366. ISSN 0127-5720,
Full text not available from this repository.Abstract
Dengue fever is one of major health problem around the world including Malaysia. It is caused by the arthropode-borne flavivirus and transmitted by the bite of the Aedes aegypti or Aedes albopictus mosquito infected with one of the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, or DENV-4). In this study, a screening exercise of various Malaysian medicinal plants showed that the extracts of Lawsonia inermis, Dryobalanops aromatica, Punica granatum, Zizyphus jujuba Lam. and Zingiber zerumbet exhibited potent inhibitory activity against NS2B-NS3 serine protease. The methanol extracts of Dryobalanops aromatica showed inhibition of 99.70 % at concentration of 200 µg/mL with IC50 value of 0.30 ± 0.16 µg/mL. © 2019, Malaysian Society for Parasitology. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education through the Trans Disciplinary Research Grant Scheme (TR001B-2014A), USIM C (PPP/ UCG-0116/FPQS/30/14316), Postgraduate Research Grant, PPP (PG101-2016A) |
| Uncontrolled Keywords: | Culicidae; Aedes; C quinquefasciatus |
| Subjects: | B Philosophy. Psychology. Religion > BP Islam. Bahaism. Theosophy, etc Q Science > QD Chemistry R Medicine |
| Divisions: | Academy of Islamic Studies > Dept of Al-Quran & Al- Hadith Centre for Foundation Studies in Science > Chemistry Division Faculty of Medicine Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 23 Jan 2020 08:13 |
| Last Modified: | 23 Jan 2020 08:13 |
| URI: | http://eprints.um.edu.my/id/eprint/23552 |
Actions (login required)
 |
View Item |
