α-glucosidase inhibitors isolated from Mimosa pudica L.

Tasnuva, S.T. and Qamar, U.A. and Ghafoor, Kashif and Sahena, F. and Jahurul, M.H.A. and Rukshana, A.H. and Juliana, M.J. and Al-Juhaimi, Fahad Y. and Jalifah, L. and Jalal, K.C.A. and Ali, Md. Eaqub and Zaidul, I.S.M. (2019) α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research, 33 (10). pp. 1495-1499. ISSN 1478-6419

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Official URL: https://doi.org/10.1080/14786419.2017.1419224

Abstract

The aim of the study was to isolate digestive enzymes inhibitors from Mimosa pudica through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC50 values as compared to acarbose (351.02 ± 1.46 μg mL−1) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL−1, respectively. In conclusion, M. pudica could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Uncontrolled Keywords: Mimosa pudica; Fabaceae; α-glucosidase inhibitors
Subjects: Q Science > Q Science (General)
T Technology > T Technology (General)
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 23 Dec 2019 02:32
Last Modified: 23 Dec 2019 02:32
URI: http://eprints.um.edu.my/id/eprint/23274

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