Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro

Abidin, Mohamad Hamdi Zainal and Abdullah, Noorlidah and Abidin, Nurhayati Zainal (2018) Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro. International Journal of Medicinal Mushrooms, 20 (3). pp. 283-290. ISSN 1521-9437

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Official URL: https://doi.org/10.1615/IntJMedMushrooms.201802582...

Abstract

This study evaluates the in vitro inhibition of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) by Pleurotus pulmonarius extracts. The protective effect on the endothelial membrane against oxidative stress through the protection of nitric oxide bioavailability, as well as inhibition of endocan expression, was evaluated using human aortic endothelial cells (HAECs). Crude cold aqueous extract exhibited the most potent inhibitory activities against ACE and HMG-CoA reductase, with 61.79% and 44.30% inhibition, respectively. It also protected the bioavailability of NO released by HAECs, with 84.88% cell viability. The crude hot water extract was the most potent in inhibiting endocan expression, with 18.61% inhibition.

Item Type: Article
Uncontrolled Keywords: ACE; HMG-CoA reductase; medicinal mushrooms; nitric oxide; Pleurotus pulmonarius
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 Oct 2019 03:21
Last Modified: 14 Oct 2019 03:21
URI: http://eprints.um.edu.my/id/eprint/22730

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