Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology

Pakalapati, Harshini and Arumugasamy, Senthil Kumar and Jewaratnam, Jegalakshimi and Wong, Yong Jie and Khalid, Mohammad (2018) Parametric optimization of polycaprolactone synthesis catalysed by Candida antarctica lipase B using response surface methodology. Biopolymers, 109 (12). e23240. ISSN 0006-3525

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Official URL: https://doi.org/10.1002/bip.23240

Abstract

A statistical approach with D-optimal design was used to optimize the process parameters for polycaprolactone (PCL) synthesis. The variables selected were temperature (50°C-110°C), time (1-7 h), mixing speed (50-500 rpm) and monomer/solvent ratio (1:1-1:6). Molecular weight was chosen as response and was determined using matrix-assisted laser desorption/ionization time of flight (MALDI TOF). Using the D-optimal method in design of experiments, the interactions between parameters and responses were analysed and validated. The results show a good agreement with a minimum error between the actual and predicted values.

Item Type: Article
Uncontrolled Keywords: Candida Antarctica lipase B; D-optimal method; design of experiment; enzymatic polymerization; optimization; polycaprolactone
Subjects: T Technology > TP Chemical technology
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Apr 2019 03:46
Last Modified: 24 Apr 2019 03:46
URI: http://eprints.um.edu.my/id/eprint/21049

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