Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba.

Qureshi, Ahmad Kaleem; Mukhtar, Mat Ropi; Hirasawa, Yusuke; Hosoya, Takahiro; Nugroho, Alfarius Eko; Morita, Hiroshi; Shirota, Osamu; Mohamad, Khalit; Hadi, A Hamid A; Litaudon, Marc; Awang, Khalijah (2011) Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba. Chemical & Pharmaceutical Bulletin, 59 (2). pp. 291-3. ISSN 1347-5223

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Abstract

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

Item Type: Article
Creators:
  1. Qureshi, Ahmad Kaleem
  2. Mukhtar, Mat Ropi
  3. Hirasawa, Yusuke
  4. Hosoya, Takahiro
  5. Nugroho, Alfarius Eko
  6. Morita, Hiroshi
  7. Shirota, Osamu
  8. Mohamad, Khalit
  9. Hadi, A Hamid A
  10. Litaudon, Marc
  11. Awang, Khalijah
Journal or Publication Title: Chemical & Pharmaceutical Bulletin
Uncontrolled Keywords: neolamarckine; indole; Neolamarckia cadamba; Rubiaceae; inducible nitric oxide synthase activity
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: UNSPECIFIED
Depositing User: Zanaria Saupi Udin
Date Deposited: 26 Feb 2011 15:19
Last Modified: 26 Feb 2011 15:19
URI: http://eprints.um.edu.my/id/eprint/175

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