Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework

Sun, R.W.Y. and Zhang, M. and Li, D. and Zhang, Z.F. and Cai, H. and Li, M. and Xian, Y.J. and Ng, S.W. and Wong, A.S.T. (2015) Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework. Chemistry-A European Journal, 21 (51). pp. 18534-18538. ISSN 0947-6539

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Official URL: DOI: 10.1002/chem.201503656

Abstract

A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.

Item Type: Article
Uncontrolled Keywords: Cancer; Carbenes; Dithiocarbamate; Gold; Metal-Organic Frameworks
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Depositing User: Mrs. Siti Mawarni Salim
Date Deposited: 29 Jul 2016 07:58
Last Modified: 29 Jul 2016 07:58
URI: http://eprints.um.edu.my/id/eprint/16191

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