Pulmonary toxicity of instilled silver nanoparticles: Influence of size, coating and rat strain

Seiffert, J. and Hussain, F. and Wiegman, C. and Li, F. and Bey, L. and Baker, W. and Porter, A. and Ryan, M.P. and Chang, Y. and Gow, A. and Zhang, J.F. and Zhu, J. and Tetley, T.D. and Chung, K.F. (2015) Pulmonary toxicity of instilled silver nanoparticles: Influence of size, coating and rat strain. PLoS ONE, 10 (3). p. 17. ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0119726.

Preview

PDF (Pulmonary Toxicity of Instilled Silver Nanoparticles: Influence of Size, Coating and Rat Strain) Pulmonary_Toxicity_of_Instilled_Silver_Nanoparticles.pdf - Other Download (12MB)

Abstract

Particle size and surface chemistry are potential determinants of silver nanoparticle (AgNP) respiratory toxicity that may also depend on the lung inflammatory state. We compared the effects of intratracheally-administered AgNPs (20nm and 110nm; polyvinylpyrrolidone (PVP) and citrate-capped; 0.1 mg/Kg) in Brown-Norway (BN) and Sprague-Dawley (SD) rats. In BN rats, there was both a neutrophilic and eosinophilic response, while in SD rats, there was a neutrophilic response at day 1, greatest for the 20nm citrate-capped AgNPs. Eosinophilic cationic protein was increased in bronchoalveolar lavage (BAL) in BN and SD rats on day 1. BAL protein and malondialdehyde levels were increased in BN rats at 1 and 7 days, and BAL KC, CCL11 and IL-13 levels at day 1, with increased expression of CCL11 in lung tissue. Pulmonary resistance increased and compliance decreased at day 1, with persistence at day 7. The 20nm, but not the 110 nm, AgNPs increased bronchial hyperresponsiveness on day 1, which continued at day 7 for the citrate-capped AgNPs only. The 20nm versus the 110 nm size were more proinflammatory in terms of neutrophil influx, but there was little difference between the citrate-capped versus the PVP-capped AgNPs. AgNPs can induce pulmonary eosinophilic and neutrophilic inflammation with bronchial hyperresponsiveness, features characteristic of asthma.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	ISI Document Delivery No.: CC9KQ Times Cited: 0 Cited Reference Count: 44 Cited References: Albanese A, 2012, ANNU REV BIOMED ENG, V14, P1, DOI 10.1146/annurev-bioeng-071811-150124, 10.1146/annurev.bioeng-071811-150124 AshaRani PV, 2009, ACS NANO, V3, P279, DOI 10.1021/nn800596w Bae E, 2010, ENVIRON TOXICOL CHEM, V29, P2154, DOI 10.1002/etc.278 Baisch BL, 2014, PART FIBRE TOXICOL, V11, DOI 10.1186/1743-8977-11-5 Beer C, 2012, TOXICOL LETT, V208, P286, DOI 10.1016/j.toxlet.2011.11.002 Bihari P, 2008, PART FIBRE TOXICOL, V5, DOI 10.1186/1743-8977-5-14 Braydich-Stolle LK, 2010, TOXICOL SCI, V116, P577, DOI 10.1093/toxsci/kfq148 Careau E, 2002, AM J RESP CELL MOL, V26, P579 Carlson C, 2008, J PHYS CHEM B, V112, P13608, DOI 10.1021/jp712087m Cho WS, 2012, NANOTOXICOLOGY, V6, P22, DOI 10.3109/17435390.2011.552810 Cho WS, 2010, ENVIRON HEALTH PERSP, V118, P1699, DOI 10.1289/ehp.1002201 ELWOOD W, 1991, J ALLERGY CLIN IMMUN, V88, P951, DOI 10.1016/0091-6749(91)90253-K ELWOOD W, 1992, INT ARCH ALLERGY IMM, V99, P91 Foster PS, 1996, J EXP MED, V183, P195, DOI 10.1084/jem.183.1.195 Haberl N, 2013, BEILSTEIN J NANOTECH, V4, P933, DOI 10.3762/bjnano.4.105 HACZKU A, 1995, IMMUNOLOGY, V85, P598 Hsin YH, 2008, TOXICOL LETT, V179, P130, DOI 10.1016/j.toxlet.2008.04.015 Huang YS, 2007, BURNS, V33, P161, DOI 10.1016/j.burns.2006.06.020 Kim JS, 2007, NANOMED-NANOTECHNOL, V3, P95, DOI 10.1016/j.nano.2006.12.001 Kim YS, 2010, PART FIBRE TOXICOL, V7, DOI 10.1186/1743-8977-7-20 Kittler CG S., 2010, JOURNAL OF MATERIAL, V20, P512 Lankveld DPK, 2010, BIOMATERIALS, V31, P8350, DOI 10.1016/j.biomaterials.2010.07.045 Lee JJ, 2004, SCIENCE, V305, P1773, DOI 10.1126/science.1099472 Leo BF, 2013, ENVIRON SCI TECHNOL, V47, P11232, DOI 10.1021/es403377p Liu JY, 2010, ENVIRON SCI TECHNOL, V44, P2169, DOI 10.1021/es9035557 Loeschner K, 2011, PART FIBRE TOXICOL, V8, DOI 10.1186/1743-8977-8-18 Ma R, 2012, ENVIRON SCI TECHNOL, V46, P752, DOI 10.1021/es201686j Nazarenko Y, 2011, J EXPO SCI ENV EPID, V21, P515, DOI 10.1038/jes.2011.10 Nel A, 2006, SCIENCE, V311, P622, DOI 10.1126/science.1114397 OLIVENSTEIN R, 1993, J CLIN INVEST, V92, P1477, DOI 10.1172/JCI116725 Park EJ, 2011, ARCH PHARM RES, V34, P299, DOI 10.1007/s12272-011-0216-y Park EJ, 2010, ENVIRON TOXICOL PHAR, V30, P162, DOI 10.1016/j.etap.2010.05.004 PRITCHARD JN, 1985, ENVIRON RES, V36, P268, DOI 10.1016/0013-9351(85)90025-8 Quadros ME, 2011, ENVIRON SCI TECHNOL, V45, P10713, DOI 10.1021/es202770m Stebounova LV, 2011, PART FIBRE TOXICOL, V8, DOI 10.1186/1743-8977-8-5 Sung JH, 2008, INHAL TOXICOL, V20, P567, DOI 10.1080/08958370701874671 Sung JH, 2009, TOXICOL SCI, V108, P452, DOI 10.1093/toxsci/kfn246 Suresh AK, 2012, LANGMUIR, V28, P2727, DOI 10.1021/la2042058 Thorley AJ, 2013, PHARMACOL THERAPEUT, V140, P176, DOI 10.1016/j.pharmthera.2013.06.008 Vanoirbeek JAJ, 2010, AM J RESP CELL MOL, V42, P96, DOI 10.1165/rcmb.2008-0487OC WASERMAN S, 1992, J ALLERGY CLIN IMMUN, V90, P661, DOI 10.1016/0091-6749(92)90140-W Wijnhoven SWP, 2009, NANOTOXICOLOGY, V3, P109, DOI 10.1080/17435390902725914 Wills-Karp M, 1998, SCIENCE, V282, P2258, DOI 10.1126/science.282.5397.2258 Zhang W, 2011, ENVIRON SCI TECHNOL, V45, P4422, DOI 10.1021/es104205a Seiffert, Joanna Hussain, Farhana Wiegman, Coen Li, Feng Bey, Leo Baker, Warren Porter, Alexandra Ryan, Mary P. Chang, Yan Gow, Andrew Zhang, Junfeng Zhu, Jie Tetley, Terry D. Chung, Kian Fan US National Institute for Environmental Health Sciences U19ES019536; UK National Environmental Research Council NE/H012893 Funded by grants from US National Institute for Environmental Health Sciences grant number U19ES019536 (http://www.niehs.nih.gov/research/supported/index.cfm), and from the UK National Environmental Research Council grant NE/H012893 (http://www.nerc.ac.uk/research/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. 0 PUBLIC LIBRARY SCIENCE SAN FRANCISCO PLOS ONE
Uncontrolled Keywords:	Brown-norway rats, consumer spray products, ion release kinetics, intratracheal instillation, airway hyperresponsiveness, nano-silver, inhalation, inflammation, exposure, cells,
Subjects:	T Technology > T Technology (General) T Technology > TJ Mechanical engineering and machinery
Divisions:	Faculty of Engineering
Depositing User:	Mr Jenal S
Date Deposited:	25 Jul 2015 02:12
Last Modified:	04 Jul 2017 07:44
URI:	http://eprints.um.edu.my/id/eprint/13797

Actions (login required)

View Item