The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia

Atroosh, W.M. and Al-Mekhlafi, H.M. and Mahdy, M.A.K. and Surin, J. (2012) The detection of pfcrt and pfmdr1 point mutations as molecular markers of chloroquine drug resistance, Pahang, Malaysia. Malaria Journal.

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Abstract

Malaria is still a public health problem in Malaysia with chloroquine (CQ) being the first-line drug in the treatment policy of uncomplicated malaria. There is a scarcity in information about the magnitude of Plasmodium falciparum CQ resistance. This study aims to investigate the presence of single point mutations in the P. falciparum chloroquine-resistance transporter gene (pfcrt) at codons 76, 271, 326, 356 and 371 and in P. falciparum multi-drug resistance-1 gene (pfmdr1) at codons 86 and 1246, as molecular markers of CQ resistance

Item Type: Article
Uncontrolled Keywords: Malaria, Plasmodium falciparum, P. falciparum
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Nur Azzura Azzahra Jaafar
Date Deposited: 13 Jun 2014 01:21
Last Modified: 13 Jun 2014 01:21
URI: http://eprints.um.edu.my/id/eprint/10546

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