Macrodasines A—G, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuran—tetrahydrofuran and tetrahydrofuran—tetrahydropyran rings

Kam, T.S. and Tan, S.J. and Robinson, W.T. and Komiyama, K. (2011) Macrodasines A—G, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuran—tetrahydrofuran and tetrahydrofuran—tetrahydropyran rings. Tetrahedron, 67. pp. 3830-3838. ISSN 0040-4020, DOI https://doi.org/10.1016/j.tet.2011.03.099.

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Abstract

The bark extract of the Malayan Alstonia angustifoliaWall provided the spirocyclic alkaloids macrodasines A—G. The structures of the new compounds were established by analysis of the spectroscopic data and in the case of macrodasines A and B confirmed by X-ray diffraction analysis. Macrodasines A, B, C, and G incorporate fused spirocyclic tetrahydrofuran—tetrahydrofuran rings, while macrodasines D, E, and F incorporate fused tetrahydrofuran—tetrahydropyran rings. Macrodasines B, C, and E were found to show moderate levels of activity in reversing multidrug-resistance in drug-resistant KB cells.

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Department of Chemistry, University of Malaya
Uncontrolled Keywords: Spirocyclic alkaloids; NMR; X-ray; Alstonia.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 15 Oct 2014 01:51
Last Modified: 15 Oct 2014 01:51
URI: http://eprints.um.edu.my/id/eprint/10392

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