Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff

Leong, K.H. (2012) Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff. Bioorganic & Medicinal Chemistry Letters, 22 (11). pp. 3831-3836.

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Abstract

The rhizomes of Zingiber spectabile yielded a new dimeric flavonol glycoside for which the name kaempferol-3-O-(4″-O-acetyl)-α-l-rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4″-O-acetyl)-α-l-rhamnopyranoside; spectaflavoside A (1) was proposed, along with kaempferol and its four acetylrhamnosides (2–6), demethoxycurcumin (7) and curcumin (8). The structure of spectaflavoside A was elucidated by spectroscopic methods including, 1D and 2D NMR techniques. This is the first report on the occurrence of a dimeric flavonol glycoside in the Zingiberaceae and the second in nature. Spectaflavoside A was found to be a potent iron chelating agent.

Item Type: Article
Uncontrolled Keywords: Zingiber spectabile Griff.; Zingiberaceae; Dimeric flavonol glycoside; Bisflavonol glycoside; Spectaflavoside A; Iron chelating activity
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
R Medicine
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Faculty of Medicine
Depositing User: Dr. Leong Kok Hoong
Date Deposited: 22 May 2014 02:21
Last Modified: 31 Jul 2018 04:26
URI: http://eprints.um.edu.my/id/eprint/10000

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