Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus)

Elsheikh, H.A. and Ali, B.H. and Zahurin, M. and Mustafa, A.M. and Alhadrami, G. and Bashir, A.K. (2001) Comparative pharmacokinetics of theophylline in camels (Camelus dromedarius) and goats (Caprus hircus). Journal of Veterinary Medicine Series a-Physiology Pathology Clinical Medicine, 48 (10). pp. 581-586. ISSN 0931-184X, DOI

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A comparative randomized crossover study was conducted to determine the pharmacokinetics of theophylline in male and female camels (Camelus dromedarius) and goats (Caprus hircus). Theophylline is an established 'probe drug' to evaluate the drug metabolizing enzyme activity of animals. It was administered by the intravenous (i.v.) route and then intramuscularly (i.m.) at a dose of 2 mg/kg. The concentration of the drug in plasma was measured using a high-performance liquid chromatography (HPLC) technique on samples collected at frequent intervals after administration. Following i.v. injection, die overall elimination rate constant (lambda(z)) in goats was 0.006 +/- 0.00076/min and in camels was 0.0046 +/- 0.0008/min (P < 0.01). The elimination half-life (t(1/2lambdaz)) in goats (112.7 min) was lower than in camels (154.7 min) (P < 0.01). The apparent volume of distribution (V-z) and the total body clearance (Cl) in goats were 1440.1 +/- 166.6 ml/kg and 8.9 +/- 1.4 ml/min/ kg, respectively. The corresponding values in camels were 1720.3 +/- 345.3 ml/kg and 6.1 +/- 1.0 ml/ min/kg, respectively. After i.m. administration, theophylline reached a peak plasma concentration (C-max) of 1.8 +/- 0.1 and 1.7 +/- 0.2 mug/ml at a post-injection dine (T-max) of 67.5 +/- 8.6 and 122.3 +/- 6.7 min in goats and camels, respectively. The mean bioavailability (F) in both goats and camels was 0.9 +/- 0.2. The above data suggest that camels eliminate theophylline at a slower rate than goats.

Item Type: Article
Additional Information: ISI Document Delivery No.: 510AA Times Cited: 2 Cited Reference Count: 24 Elsheikh, HA Ali, BH Zahurin, M Mustafa, AM Alhadrami, G Bashir, AK Blackwell verlag gmbh Berlin
Uncontrolled Keywords: Sheep; horses; bioavailability; furosemide
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 18 Apr 2013 00:27
Last Modified: 18 Apr 2013 00:27

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