Preliminary investigation of tensile properties of welded type I collagen to be used as surgical sealant

Ghazali, M. and Kadri, Nahrizul Adib (2011) Preliminary investigation of tensile properties of welded type I collagen to be used as surgical sealant. International Journal of the Physical Sciences, 6 (36). pp. 8057-8062. ISSN 1992-1950,

Full text not available from this repository.


Type I collagen has been identified as the most abundant protein in the human body, and it has been used extensively in the healthcare industry as a biomaterial for the purposes of soft tissue repair, tissue engineering and many other areas. The aim of this study was to research the mechanical tensile strength of type I collagen when welded together for possible use as a sealant biomaterial for surgical closure. Sheets of type I collagen from calf skin were prepared using collagen granules and a 1.6 M acetic solution. The sheets were cut into smaller pieces and welded together at different widths using a magnetic heat plate. Mechanical tensile properties were subsequently determined using a tensiometer. A set of six parameters were selected as the variables of choice for the purpose of analyzing the mechanical properties, namely, the tensile stress and tensile strain at the point of failure, the maximum load that was applied to the collagen sample and the physical dimensions of each of the collagen samples. It was found that only the tensile strain at failure point is significantly different (P < 0.01) between the different groups of collagen samples. However, a conclusive decision could not be made based on this finding alone, and further investigations are warranted. © 2011 Academic Journals.

Item Type: Article
Additional Information: Export Date: 11 December 2012 Source: Scopus Language of Original Document: English Correspondence Address: Kadri, N. A.; Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; email: References: Chandran, P., Barocas, V., Microstructural mechanics of collagen gels in confined compression: Poroelasticity, viscoelasticity, and collapse (2004) J. Biomech. Eng., pp. 126-152; Chen, S., Wright, N., Humphrey, J., Heat-induced changes in the mechanics of a collagenous tissue: Isothermal, isotonic shrinkage (1998) J. Biomech. Eng., pp. 120-382; Cheung, H., Lau, K., Lu, T., Hui, D., A critical review on polymer-based bio-engineered materials for scaffold development (2007) Composites Part B: Engineering, 38 (3), pp. 291-300; Feng, Z., Yamato, M., Akutsu, T., Nakamura, T., Okano, T., Umezu, M., Investigation on the mechanical properties of contracted collagen gels as a scaffold for tissue engineering (2003) Artificial Organs, 27 (1), pp. 84-91; Feng, Z., Ishibashi, M., Nomura, Y., Kitajima, T., Nakamura, T., (2006) Constraint stress, microstructural characteristics, and enhanced mechanical properties, 30 (11), pp. 870-877; Kim, B., Baez, C., Atala, A., Biomaterials for tissue engineering (2000) World J. Urology, 18 (1), pp. 2-9; Lu, Q., Ganesan, K., Simionescu, D., Vyavahare, N., Novel porous aortic elastin and collagen scaffolds for tissue engineering (2004) Biomaterials, 25 (22), pp. 5227-5237; Pachence, J., Collagen-based devices for soft tissue repair (1996) J. Biomed. Mat. Res., 33 (1), pp. 35-40; Park, J., Bronzino, J., (2003) Biomaterials: Principles and applications, pp. 117-139. , CRC Press, Boca Raton; Rocha, L., Goissis, G., Rossi, M., Biocompatibility of anionic collagen matrix as scaffold for bone healing (2002) Biomaterials, 23 (2), pp. 449-456; Sturgis, J., Robinson, J., Voytik-Harbin, S., Tensile mechanical properties of three-dimensional type I collagen extracellular matrices with varied microstructure (2002) J. Biomech. Eng., 124, p. 214; Tiyek, I., Gemci, R., Türkolu, S., Comparison of physical properties of sutures in medical liquids (2011) Int. J. Phys. Sci., 6 (8), pp. 2158-2168; Wright, N., Humphrey, J., Denaturation of collagen via heating: An irreversible rate process (2002) Ann. Review Biomed. Eng., 4 (1), pp. 109-128
Uncontrolled Keywords: Biomaterials Collagen Sealant
Subjects: T Technology > T Technology (General)
Divisions: Faculty of Engineering
Depositing User: Mr. Mohammed Salim Abd Rahman
Date Deposited: 13 Mar 2013 07:31
Last Modified: 20 Jan 2021 08:18

Actions (login required)

View Item View Item