Mechanical behaviour of in-situ chondrocytes subjected to different loading rates: a finite element study

Moo, E.K. and Herzog, W. and Han, S.K. and Abu Osman, Noor Azuan and Pingguan-Murphy, Belinda and Federico, S. (2012) Mechanical behaviour of in-situ chondrocytes subjected to different loading rates: a finite element study. Biomechanics and Modeling in Mechanobiology, 11 (7). pp. 983-993. ISSN 1617-7940,

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Experimental findings indicate that in-situ chondrocytes die readily following impact loading, but remain essentially unaffected at low (non-impact) strain rates. This study was aimed at identifying possible causes for cell death in impact loading by quantifying chondrocyte mechanics when cartilage was subjected to a 5 nominal tissue strain at different strain rates. Multi-scale modelling techniques were used to simulate cartilage tissue and the corresponding chondrocytes residing in the tissue. Chondrocytes were modelled by accounting for the cell membrane, pericellular matrix and pericellular capsule. The results suggest that cell deformations, cell fluid pressures and fluid flow velocity through cells are highest at the highest (impact) strain rate, but they do not reach damaging levels. Tangential strain rates of the cell membrane were highest at the highest strain rate and were observed primarily in superficial tissue cells. Since cell death following impact loading occurs primarily in superficial zone cells, we speculate that cell death in impact loading is caused by the high tangential strain rates in the membrane of superficial zone cells causing membrane rupture and loss of cell content and integrity.

Item Type: Article
Additional Information: Moo, E K Herzog, W Han, S K Abu Osman, N A Pingguan-Murphy, B Federico, S eng Canadian Institutes of Health Research/Canada Research Support, Non-U.S. Gov't Germany 2012/01/12 06:00 Biomech Model Mechanobiol. 2012 Sep;11(7):983-93. Epub 2012 Jan 11.
Uncontrolled Keywords: Finite element modelling, Impact loading, Chondrocyte mechanics, Cell membrane damage, Osteoarthritis, Cartilage mechano-biology
Subjects: T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Faculty of Engineering
Depositing User: Mr Jenal S
Date Deposited: 11 Jan 2013 02:32
Last Modified: 07 Feb 2019 08:21

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