Notch signaling in benign and malignant ameloblastic neoplasms

Nakano, K. and Siar, C.H. and Tsujigiwa, H. and Nagatsuka, H. and Nagai, N. and Kawakami, T. (2008) Notch signaling in benign and malignant ameloblastic neoplasms. European Journal of Medical Research, 13 (10). pp. 476-480. ISSN 0949-2321,


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Background: In general, Notch is a representative signal which controls morphosis and differentiation of cells, but its role in human odontogenic neoplasms, especially in ameloblastoma and its malignant counter-part, ameloblastic carcinoma, is not known. Methods: We examined Notch1 peptide and its gene (mRNA) in an ameloblastoma (case 1: 27-year-old female, right mandibular tumor) and an ameloblastic carcinoma (case 2: 93-year-old female, right mandibular tumor), using immunohistochemistry (IHC) and in situ hybridization (ISH) techniques. Results: Notch1 intracellular domain (NICD) Positive products were observed in the cells at the peripheral layer of most proliferating epithelial tumor nests in case 1. In case 2, positive products were similarly detected. In particular, small numbers of mitoses were identified in the nuclear region With intense NICE positive reaction. Conclusions: Notch signaling plays some role in cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells of odontogenic neoplasms including ameloblastoma and ameloblastic carcinoma. Notch I may also contribute to Cell cycle arrest induced by Notch1 activation in ameloblastic carcinoma.

Item Type: Article
Additional Information: ISI Document Delivery No.: 370LJ Times Cited: 10 Cited Reference Count: 19 Cited References: ATTAVANISTSAKON.S, 1999, SCIENCE, V284, P770 Blaumueller CM, 1997, CELL, V90, P281, DOI 10.1016/S0092-8674(00)80336-0 Gardner DG, 2005, WHO CLASSIFICATION T, P296 Kawakami T, 2004, EUR J MED RES, V9, P533 Kawai T, 2008, CURRENT EXPERIMENTAL STUDY FOR TREATMENT OF CLEFT LIP AND PALATE, P1 Kawakami T, 2005, EUR J MED RES, V10, P475 Lindsell CE, 1996, MOL CELL NEUROSCI, V8, P14, DOI 10.1006/mcne.1996.0040 Maillard I, 2003, IMMUNITY, V18, P587, DOI 10.1016/S1074-7613(03)00119-5 Mitsiadis TA, 1998, DEV BIOL, V204, P420, DOI 10.1006/dbio.1998.9092 Mitsiadis TA, 1999, EXP CELL RES, V246, P312, DOI 10.1006/excr.1998.4285 Ohishi K, 2003, SEMIN CELL DEV BIOL, V14, P143, DOI 10.1016/S1084-9521(02)00183-0 Sciubba JJ, 2005, WHO CLASSIFICATION T, P287 Shimizu T, 2007, EUR J MED RES, V12, P515 Shou JY, 2001, CANCER RES, V61, P7291 SIAR CH, 2006, ORAL MED PATHOL, V11, P35 Sriuranpong V, 2001, CANCER RES, V61, P3200 Weijzen S, 2002, NAT MED, V8, P979, DOI 10.1038/nm754 Weinmaster G, 1997, MOL CELL NEUROSCI, V9, P91, DOI 10.1006/mcne.1997.0612 ZAGOURAS P, 1995, P NATL ACAD SCI USA, V92, P6414, DOI 10.1073/pnas.92.14.6414 Nakano, K. Siar, C. H. Tsujigiwa, H. Nagatsuka, H. Nagai, N. Kawakami, T. I holzapfel verlag gmbh Munich
Uncontrolled Keywords: Odontogenic ameloblastoma ameloblastic carcinoma Notch malignancy expression patterns receptor hematopoiesis ligand cells
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Ms Nursyafiqah Abd Malek
Date Deposited: 09 Jan 2013 01:13
Last Modified: 09 Jan 2013 01:13

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