Immunohistochemical observation of notch signaling in a case of calcifying cystic odontogenic tumor

Nakano, K. and Siar, C.H. and Tomida, M. and Matsuura, S. and Tsujigiwa, H. and Nagatsuka, H. and Kawakami, T. (2010) Immunohistochemical observation of notch signaling in a case of calcifying cystic odontogenic tumor. Journal of Hard Tissue Biology, 19 (3). pp. 147-152. ISSN 1341-7649, DOI


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Odontogenesis is a complex biological process both with epithelial and mesenchymal tissues, and this process directly reflects the development of odontogenic neoplasms. Therefore, we have examined Notch signaling in a case of calcifying cystic odontogenic tumor, with ameloblastic fibroma and odontogenic myxoma cases as controls. In these specimens, Notch-positive-products were present both in the epithelial and ectomesenchymal components in the calcifying cystic odontogenic tumor and the ameloblastic fibroma case, but negative in the odontogenic myxoma case, having no odontogenic epithelial islands to IHC and ISH examinations. Therefore, the examination results suggest that Notch signaling plays some important roles in cytological differentiation or acquisition of tissue-specific characteristics between odontogenic epithelium and odontogenic ectomesenchymal tissues.

Item Type: Article
Additional Information: ISI Document Delivery No.: 706JF Times Cited: 3 Cited Reference Count: 26 Cited References: Artavanis-Tsakonas S, 1999, SCIENCE, V284, P770, DOI 10.1126/science.284.5415.770 Blaumueller CM, 1997, CELL, V90, P281, DOI 10.1016/S0092-8674(00)80336-0 Chuah KS, 2009, J HARD TISSUE BIOL, V18, P63 Kawakami T, 2004, EUR J MED RES, V9, P533 KAWAKAMI T, 2009, CELL DIFFER, P1 Kawai T, 2008, CURRENT EXPERIMENTAL STUDY FOR TREATMENT OF CLEFT LIP AND PALATE, P1 KAWAKAMI T, 2007, MICROSCO MICROANAL, V13, P328 Kawakami T, 2005, EUR J MED RES, V10, P475 Kumamoto H, 2008, J ORAL PATHOL MED, V37, P228, DOI 10.1111/j.1600-0714.2007.00629.x Leong KG, 2006, BLOOD, V107, P2223, DOI 10.1182/blood-2005-08-3329 MITSIADIS TA, 1995, J CELL BIOL, V130, P407, DOI 10.1083/jcb.130.2.407 Mitsiadis TA, 1998, DEV BIOL, V204, P420, DOI 10.1006/dbio.1998.9092 Mitsiadis TA, 1997, DEVELOPMENT, V124, P1473 MURAOKA R, 2008, J MATSUMOTO DENT U S, V34, P13 NAGATSUKA H, 2009, ORAL MED PATHOL, V13, P81 Nakano K, 2008, EUR J MED RES, V13, P476 Nakano K, 2008, ORAL MED PATHOL, V12, P53, DOI 10.3353/omp.12.53 Nakano K, 2008, J HARD TISSUE BIOL, V17, P79 Praetorius F, 2005, WHO CLASSIFICATION T, P313 Sathi GSA, 2008, J HARD TISSUE BIOL, V17, P63 Siar CH, 2010, ORAL SURG ORAL MED O, V110, P224, DOI 10.1016/j.tripleo.2010.03.009 SIAR CH, 2006, ORAL MED PATHOL, V11, P35 Siar CH, 2010, J ORAL PATHOL MED, V39, P552, DOI 10.1111/j.1600-0714.2009.00871.x Siar CH, 2010, EUR J MED RES, V15, P180 Yin XD, 2009, J HARD TISSUE BIOL, V18, P19 ZAGOURAS P, 1995, P NATL ACAD SCI USA, V92, P6441 Nakano, Keisuke Siar, Chong Huat Tomida, Mihoko Matsuura, Sachiko Tsujigiwa, Hidetsugu Nagatsuka, Hitoshi Kawakami, Toshiyuki Japan Society for the Promotion of Science20592349; Matsumoto Dental University This study was supported in part by a Grant-in Aid for Scientific Research (C) (20592349) from the Japan Society for the Promotion of Science and also supported in part by a Promotion Research Grand 2009 of Matsumoto Dental University. The authors thank to Professor DM Carlson, Matsumoto Dental University, for his critical reading of the manuscript. Journal hard tissue biology Minato ku
Uncontrolled Keywords: Calcifying cystic odontogenic tumor Notch signalin Notch Jagged Cell differentiation epithelial-mesenchymal interactions growth-factor cell fate expression ameloblastomas receptors neoplasms tooth
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Ms Nursyafiqah Abd Malek
Date Deposited: 10 Jan 2013 00:03
Last Modified: 10 Jan 2013 00:03

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