Ferroptosis-related long noncoding RNA signature predicts prognosis of clear cell renal carcinoma

Liu, J. W. and Supandi, Farahaniza and Dhillon, Sarinder Kaur (2022) Ferroptosis-related long noncoding RNA signature predicts prognosis of clear cell renal carcinoma. Folia Biologica, 68 (1). pp. 1-15. ISSN 0015-5500,

Full text not available from this repository.


Clear cell renal cell carcinoma (ccRCC) is very common and accounts for most kidney cancer deaths. While many studies are being conducted in finding the prognostic signatures of ccRCC, we be-lieve that ferroptosis, which involves programmed cell death dependent on iron accumulation, has ther-apeutic potential in ccRCC. Recent research has shown that long noncoding RNAs (lncRNAs) are in-volved in ferroptosis-related tumour processes and are closely related to survival in patients with ccRCC. Hence, in this study we aim to further explore the role of ferroptosis-related lncRNAs (FRLs) in ccRCC, hoping to establish a signature to predict the survival outcome of ccRCC. We analysed transcriptome data from The Cancer Genome Atlas database (TCGA) and ferroptosis-related genes (FRGs) from FerrDb to identify FRLs using Pearson's correlation. Lasso Cox regression analysis and multivariate Cox pro-portional hazards models screened seventeen opti-mal FRLs for developing prognostic signatures. Kaplan-Meier survival curves and ROC curves were then plotted for validating the sensitivity, specificity, and accuracy of the identified signatures. Gene Set Enrichment Analysis and CIBERSORT algorithm were deployed to explore the role of these FRLs in the tumour microenvironment. It was concluded that these models demonstrate excellent performance in predicting prognosis among patients with ccRCC, also indicating association with the clinicopathologic parameters such as tumour grade, tumour stage and tumour immune infiltration. In conclusion, our find-ings provide novel insights into ferroptosis-related lncRNAs in ccRCC, which are important targets for investigating the tumorigenesis of ccRCC.

Item Type: Article
Uncontrolled Keywords: Cancer; Gene; Form
Subjects: Q Science > QM Human anatomy
Divisions: Faculty of Science
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 15 Sep 2023 08:06
Last Modified: 15 Sep 2023 08:06
URI: http://eprints.um.edu.my/id/eprint/41268

Actions (login required)

View Item View Item