Synthesis and characterization of amino acid-derived hydantoins

Chin, Ee-Zhen and Tan, Siow-Ping and Liew, Sook-Yee and Kurz, Thomas (2021) Synthesis and characterization of amino acid-derived hydantoins. Malaysian Journal of Chemistry, 23 (2). pp. 19-25. ISSN 2550-1658,

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The Urech hydantoin synthesis is the chemical reaction of amino acids with potassium cyanate and hydrochloric acid, which allows access to hydantoins and its derivatives. Most of them are biologically active with varieties of structural diversity that make them synthetically attractive. A series of hydantoins were synthesized from various α-amino acids in a reaction with hydrochloric acid and ethanol as the first step, and with potassium cyanate as the second step for the formation of ureido derivatives. Lastly, the cyclization of ureido derivatives yielded the desired hydantoin products. All hydantoins were obtained in a good yield and fully characterized by NMR and IR spectroscopy. This strategy provides a variety of biologically significant hydantoin derivatives. © 2021 Malaysian Institute of Chemistry. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Alanine;Glycine;Phenylalanine;Hydantoins;Urech hydantoin synthesis
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science
Depositing User: Ms Zaharah Ramly
Date Deposited: 01 Nov 2022 07:02
Last Modified: 01 Nov 2022 07:02

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