Drug-coated balloon treatment in coronary artery disease: Recommendations from an Asia-Pacific Consensus Group

Her, Ae-Young and Shin, Eun-Seok and Bang, Liew Houng and Nuruddin, Amin Ariff and Tang, Qiang and Hsieh, I-Chang and Hsu, Jung-Cheng and Kiam, Ong Tiong and Qiu, ChunGuang and Qian, Jie and Wan Ahmad, Wan Azman and Ali, Rosli Mohd (2021) Drug-coated balloon treatment in coronary artery disease: Recommendations from an Asia-Pacific Consensus Group. Cardiology Journal, 28 (1). pp. 136-149. ISSN 1897-5593, DOI https://doi.org/10.5603/CJ.a2019.0093.

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Coronary artery disease (CAD) is currently the leading cause of death globally, and the prevalence of this disease is growing more rapidly in the Asia-Pacific region than in Western countries. Although the use of metal coronary stents has rapidly increased thanks to the advancement of safety and efficacy of newer generation drug eluting stent (DES), patients are still negatively affected by some the inherent limitations of this type of treatment, such as stent thrombosis or restenosis, including neoatherosclerosis, and the obligatory use of dual antiplatelet therapy (DAPT) with unknown optimal duration. Drug-coated balloon (DCB) treatment is based on a leave-nothing-behind concept and therefore it is not limited by stent thrombosis and long-term DAPT; it directly delivers an anti-proliferative drug which is coated on a balloon after improving coronary blood flow. At present, DCB treatment is recommended as the first-line treatment option in metal stent-related restenosis linked to DES and bare metal stent. For de novo coronary lesions, the application of DCB treatment is extended further, for conditions such as small vessel disease, bifurcation lesions, and chronic total occlusion lesions, and others. Recently, several reports have suggested that fractional flow reserve guided DCB application was safe for larger coronary artery lesions and showed good long-term outcomes. Therefore, the aim of these recommendations of the consensus group was to provide adequate guidelines for patients with CAD based on objective evidence, and to extend the application of DCB to a wider variety of coronary diseases and guide their most effective and correct use in actual clinical practice.

Item Type: Article
Funders: None
Uncontrolled Keywords: Drug-coated balloon; Asia-Pacific; Coronary artery disease; De novo lesion; In-stent restenosis
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 30 May 2022 08:17
Last Modified: 30 May 2022 08:17
URI: http://eprints.um.edu.my/id/eprint/34515

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