Surgical site infection and development of antimicrobial sutures: A review

Chua, R. A. H. W. and Lim, Soo Kun and Chee, Chin Fei and Chin, Sek Peng and Kiew, Lik Voon and Sim, Kae Shin and Tay, Sun Tee (2022) Surgical site infection and development of antimicrobial sutures: A review. European Review for Medical and Pharmacological Sciences, 26 (3). pp. 828-845. ISSN 1128-3602,

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Sutures are used to facilitate wound healing and play an important role in ensuring the success of surgical interventions in healthcare facilities. Suture-associated surgical site infection (SSI) may develop when bacterial pathogens colonize the suture surface and establish biofilms that are highly resistant to antibiotic treatment. The outcome of SSI affects postoperative care, leading to high rates of morbidity and mortality, prolonged hospitalization, and increased financial burden. Antimicrobial sutures coated with antiseptics such as triclosan and chlorhexidine have been used to minimize the occurrence of SSI. However, as the efficacy of antiseptic-based sutures may be affected due to the emergence of resistant bacterial strains, new approaches for the development of alternative antimicrobial sutures are necessary. This review provides an update and outlook of various approaches in the design and development of antimicrobial sutures. Attaining a zero SSI rate will be possible with the advancement in suturing technology and implementation of good infection control practice in clinical settings.

Item Type: Article
Funders: Universiti Malaya, Malaysia [IIRG 003C-19FNW] [ST029-2020]
Uncontrolled Keywords: Antimicrobial sutures; Biofilm; Review; Suture; Surgical site infection
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 04 Aug 2022 00:50
Last Modified: 04 Aug 2022 00:50

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