Antiproliferative activity of aqueous extract of Piper betle L. and Psidium guajava L. on KB and HeLa cell lines

Razak, Fathilah Abdul and Sujata, R. and Norhanom, A.W. and Adenan, M.I. (2010) Antiproliferative activity of aqueous extract of Piper betle L. and Psidium guajava L. on KB and HeLa cell lines. Journal of Medicinal Plants Research, 4 (11). pp. 987-990. ISSN 1996-0875,


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The aim of the present study was to assess the effect of the aqueous extracts of Psidium guajava and Piper betle plants on the proliferation of cancerous cell lines, that is, KB and HeLa cell line. Using the neutral red cytotoxicity assay, the IC(50) of P. guajava and P. betle were determined at 29.0 +/- 0.4 and 29.5 +/- 0.3 mu g/ml, respectively, indicating both plant extracts equally potent for the treatment of cancerous oral epidermal lesions. However, a less potent anti-proliferative activity was recorded by P. guajava towards HeLa cell line with an IC(50) of 51.0 +/- 0.6 mu g/ml, whereas P. betle extract did not affect the proliferation of HeLa.

Item Type: Article
Additional Information: ISI Document Delivery No.: 631OG Times Cited: 1 Cited Reference Count: 17 Cited References: Kaileh M, 2007, J ETHNOPHARMACOL, V113, P510, DOI 10.1016/j.jep.2007.07.008 Nalina T., 2007, American Journal of Biochemistry and Biotechnology, V3, P10 SHUN CY, 2007, ARCH TOXICOL, V81, P45 Wang Bo, 2007, Wei Sheng Yan Jiu, V36, P298 Manosroi J, 2006, CANCER LETT, V235, P114, DOI 10.1016/j.canlet.2005.04.021 Rahman A, 2006, J Insect Sci, V6, P1, DOI 10.1673/1536-2442(2006)61:BOSPDT2.0.CO;2 FATHILAH AR, 2006, J ORAL SCI, V48, P71 FATHILAH AR, 2005, THESIS U MALAYA *IICB, 2004, 1 HERB BAS CANC CUR FATHILAH AR, 2003, J ORAL SCI, V45, P201 SEO N, 2003, ANTICANCER RES, V25 DEOLIVEIRA TR, 2003, GENET MOL BIOL, V26, P551 INDU BJ, 2000, HERBS GREEN PHARM MA HOBERT I, 1998, GUAVA MED SAFE CHEAP NORLIA Y, 1992, PENANAMAN JAMBU BATU Borenfreund E, 1984, J TISSUE CULTURE MET, V9, P7 PONGLUX D, MED PLANTS Fathilah, A. R. Sujata, R. Norhanom, A. W. Adenan, M. I. University of MalayaFS157-2008B The cell lines were obtained from a research laboratory at the Institute of Post Graduate Studies, University of Malaya. This study was supported by the University of Malaya short term vote FS157-2008B. Academic journals Victoria island
Uncontrolled Keywords: Antiproliferative KB cells heLa cells Psidium guajava Piper betle medicinal-plants
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Biology
Depositing User: Mr Ahmad Azwan Azman
Date Deposited: 14 Jun 2012 07:25
Last Modified: 23 Dec 2019 07:43

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