Lim, Xin Yi and Chan, Janice Sue Wen and Tan, Terence Yew Chin and Teh, Bee Ping and Abd Razak, Mohd Ridzuan Mohd and Mohamad, Saharuddin and Mohamed, Ami Fazlin Syed (2021) Andrographis paniculata(Burm. F.) Wall. Ex Nees, Andrographolide, and Andrographolide Analogues as SARS-CoV-2 Antivirals? A rapid review. Natural Product Communications, 16 (5). ISSN 1934-578X, DOI https://doi.org/10.1177/1934578X211016610.
Full text not available from this repository.Abstract
Drug repurposing is commonly employed in the search for potential therapeutic agents. Andrographis paniculata, a medicinal plant commonly used for symptomatic relief of the common cold, and its phytoconstituent andrographolide, have been repeatedly identified as potential antivirals against SARS-CoV-2. In light of new evidence emerging since the onset of the COVID-19 pandemic, this rapid review was conducted to identify and evaluate the current SARS-CoV-2 antiviral evidence for A. paniculata, andrographolide, and andrographolide analogs. A systematic search and screen strategy of electronic databases and gray literature was undertaken to identify relevant primary articles. One target-based in vitro study reported the 3CL(pro) inhibitory activity of andrographolide as being no better than disulfiram. Another Vero cell-based study reported potential SARS-CoV-2 inhibitory activity for both andrographolide and A. paniculata extract. Eleven in silico studies predicted the binding of andrographolide and its analogs to several key antiviral targets of SARS-CoV-2 including the spike protein-ACE-2 receptor complex, spike protein, ACE-2 receptor, RdRp, 3CL(pro), PLpro, and N-protein RNA-binding domain. In conclusion, in silico and in vitro studies collectively suggest multi-pathway targeting SARS-CoV-2 antiviral properties of andrographolide and its analogs, but in vivo data are needed to support these predictions.
| Item Type: | Article |
|---|---|
| Funders: | Institute for Medical Research, Head Centre of Herbal Medicine Research Centre |
| Uncontrolled Keywords: | COVID-19; Andrographolide; Andrographis paniculata; Antiviral; Herbal medicines; Bioactivity |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 01 Mar 2022 07:20 |
| Last Modified: | 01 Mar 2022 07:20 |
| URI: | http://eprints.um.edu.my/id/eprint/28606 |
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