Marine algae as emerging therapeutic alternatives for depression: A review

Subermaniam, Kogilavani and Teoh, Seong Lin and Yow, Yoon-Yen and Tang, Yin Quan and Lim, Lee Wei and Wong, Kah Hui (2021) Marine algae as emerging therapeutic alternatives for depression: A review. Iranian Journal of Basic Medical Sciences, 24 (8). pp. 997-1013. ISSN 2008-3866, DOI

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Depression is a complex heterogeneous brain disorder characterized by a range of symptoms, resulting in psychomotor and cognitive disabilities and suicidal thoughts. Its prevalence has reached an alarming level affecting millions of people globally. Despite advances in current pharmacological treatments, the heterogenicity of clinical response and incidences of adverse effects have shifted research focus to identification of new natural substances with minimal or no adverse effects as therapeutic alternatives. Marine algae-derived extracts and their constituents are considered potential sources of secondary metabolites with diverse beneficial effects. Marine algae with enormous health benefits are emerging as a natural source for discovering new alternative antidepressants. Its medicinal properties exhibited shielding efficacy against neuroinflammation, oxidative stress, and mitochondrial dysfunction, which are indicated to underlie the pathogenesis of many neurological disorders. Marine algae have been found to ameliorate depressive-like symptoms and behaviors in preclinical and clinical studies by restoring monoaminergic neurotransmission, hypothalamic-pituitary-adrenal axis function, neuroplasticity, and continuous neurogenesis in the dentate gyrus of the hippocampus via modulating brain-derived neurotrophic factors and antineuroinflammatory activity. Although antidepressant effects of marine algae have not been validated in comparison with currently available synthetic antidepressants, they have been reported to have effects on the pathophysiology of depression, thus suggesting their potential as novel antidepressants. In this review, we analyzed the currently available research on the potential benefits of marine algae on depression, including their effects on the pathophysiology of depression, potential clinical relevance of their antidepressant effects in preclinical and clinical studies, and the underlying mechanisms of these effects.

Item Type: Article
Funders: Public Service Department of Malaysia (KKM5007/92/730525085970 (LDP 1) (6)), Ministry of Health of Malaysia (KKM5007/92/730525085970 (LDP 1) (6))
Uncontrolled Keywords: Antidepressants; Complementary medicine; Depression; Microalgae; Neuroinflammation; Neuronal plasticity; Seaweed
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 08 Aug 2022 08:27
Last Modified: 08 Aug 2022 08:27

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