Biological activities of paeonol in cardiovascular diseases: A review

Vellasamy, Shalini and Murugan, Dharmani and Abas, Razif and Alias, Aspalilah and Seng, Wu Yuan and Woon, Choy Ker (2021) Biological activities of paeonol in cardiovascular diseases: A review. Molecules, 26 (16). ISSN 1420-3049, DOI

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Paeonol is a naturally existing bioactive compound found in the root bark of Paeonia suffruticosa and it is traditionally used in Chinese medicine for the prevention and management of cardiovascular diseases. To date, a great deal of studies has been reported on the pharmacological effects of paeonol and its mechanisms of action in various diseases and conditions. In this review, the underlying mechanism of action of paeonol in cardiovascular disease has been elucidated. Recent studies have revealed that paeonol treatment improved endothelium injury, demoted inflammation, ameliorated oxidative stress, suppressed vascular smooth muscle cell proliferation, and repressed platelet activation. Paeonol has been reported to effectively protect the cardiovascular system either employed alone or in combination with other traditional medicines, thus, signifying it could be a hypothetically alternative or complementary atherosclerosis treatment. This review summarizes the biological and pharmacological activities of paeonol in the treatment of cardiovascular diseases and its associated underlying mechanisms for a better insight for future clinical practices.

Item Type: Article
Funders: Universiti Teknologi MARA (600-RMC/GPK 5/3 (269/2020))
Uncontrolled Keywords: Paeonol; Cardiovascular diseases; Anti-inflammatory; Anti-oxidant; Anti-apoptotic; Vascular tone regulation
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 14 Mar 2022 06:45
Last Modified: 14 Mar 2022 06:45

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